The effect of the serum lipid levels on vertebral fractures and bone mineral density is not clear. A total of 107 postmenopausal women aged 45–79 examined by lumbar spine, hip and radius bone mineral density (BMD) measurements, lateral dorsal and lumbar spine radiographies, routine blood tests and serum lipids [total cholesterol (TC), triglyceride (TG), HDL-C, LDL-C, VLDL-C]. Demographic and lifestyle characteristics were collected. Eighty-nine radiographies with good technical properties were scored by the Kleerekoper method. Patients with vertebrae fractures had lower levels of TC, TG, LDL-C than the patients without vertebrae fractures. Total cholesterol level was the most prominent factor affecting the vertebral fracture existence. An increase of 1 mg/dl total cholesterol decreases the risk of vertebrae fracture by 2.2%. The existence of osteoporosis due to T score was not influencing the lipid values. TC and LDL-C were weakly associated with BMD at the forearm UD region after the adjustment for the possible confounders. This study shows that the serum lipids have impact on vertebrae fracture existence rather than BMD alterations.
This is a preview of subscription content, access via your institution.
Buy single article
Instant access to the full article PDF.
Price excludes VAT (USA)
Tax calculation will be finalised during checkout.
Kenny AM, Prestwood KM (2000) Osteoporosis, pathogenesis, diagnosis and treatment in older adults. Rheum Dis Clin N Am 26(3):569–591. doi:10.1016/S0889-857X(05)70157-5
Brown JP, Josse RG (2002) 2002 Clinical practice guidelines for the diagnosis and management of osteoporosis in Canada. CMAI 167(Suppl 10):s1–s34
Hacyzyński J, Jakimiuk AJ (2001) Vertebral fractures: a hidden problem of osteoporosis. Med Sci Monit 7:1108–1117
Tintut Y, Morony S, Demer LL (2004) Hyperlipidemia promotes osteoclastic potential of bone marrow cells ex vivo. Arterioscler Thromb Biol 24:e6–e10. doi:10.1161/01.ATV.0000112023.62695.7f
Solomon DH, Avorn J, Canning CF, Wang PS (2005) Lipid levels and bone mineral density. Am J Med 118(12):1414. doi:10.1016/j.amjmed.2005.07.031
Adami S, Braga V, Zamboni M, Gatti D, Rossini M, Bakri J et al (2004) Relationship between lipids and bone mass in 2 cohorts of healthy women and men. Calcif Tissue Int 74:136–142. doi:10.1007/s00223-003-0050-4
Yamaguchi T, Sugimoto T, Yano S, Yamauchi M, Sowa H, Chen Q et al (2002) Plasma lipids and osteoporosis in postmenopausal women. Endocr J 49(2):211–217
Rolland-Cachera MF, Cole TJ, Sempe M (1991) Body mass index variations: centiles from birth to 87 years. Eur J Clin Nutr 45:13–21
Lems WF, Jahangier ZN, Raymakers JA, Jacobs JW, Bijlsma JW (1997) Methods to score vertebral deformities in patients with rheumatoid arthritis. Br J Rheumatol 36:220–224. doi:10.1093/rheumatology/36.2.220
Link TM, Majumdar S (2003) Osteoporosis imaging. Radio Clin N Am 41:813–839. doi:10.1016/S0033-8389(03)00059-9
Bagger YZ, Ramussen HB, Alexandersen P, Werge T, Christiansen C, Tankó LB (2007) PERF study group. Links between cardiovascular disease and osteoporosis in postmenopausal women:serum lipids or atherosclerosis per se? Osteoporos Int 18:505–512. doi:10.1007/s00198-006-0255-2
Tanko LB, Bagger YZ, Nielsen SB, Christiansen C (2003) Does serum cholesterol contribute to vertebral bone loss in postmenopausal women. Bone 32:8–14. doi:10.1016/S8756-3282(02)00918-3
White PC (1994) Genetic diseases of steroid metabolism. Vitam Horm 49:131–195. doi:10.1016/S0083-6729(08)61147-4
Tikkanen MJ, Vihma V, Höckerstedt A, Jauhiainen M, Helisten H, Kaamanen M (2002) Lipophilic oestrogen derivatives contained in lipoprotein particles. Acta Physiol Scand 176:117–121. doi:10.1046/j.1365-201X.2002.01022.x
Mudali S, Dobs AS, Ding J, Cauley JA, Szklo M, Golden SH (2005) Endogenous postmenopausal hormones and serum lipids: the atherosclerosis risk in communities study. J Clin Endocrinol Metab 90:1202–1209. doi:10.1210/jc.2004-0744
Parhami F, Jackson SM, Tintut Y, Le V, Balucan JP, Territo M et al (1999) Atherogenic diet and minimally oxidized low density lipoprotein ınhibit osteogenic and promote adipogenic differentiation of marrow stromal cells. J Bone Miner Res 14(12):2067–2078. doi:10.1359/jbmr.19188.8.131.527
Parhami F, Mody N, Gharavi N, Ballard AJ, Tintut Y, Demer LL (2002) Role of cholesterol biosynthetic pathway in osteoblastic differentiation of marrow stromal cells. J Miner Res 17(11):1997–2003. doi:10.1359/jbmr.2002.17.11.1997
Kha T, Basseri B, Shouhed D, Richardson J, Tetradis S, Hahn TJ et al (2004) Oxysterols regulate differentiation of mesenchymal stem cells: pro-bone and anti-fat. J Bone Miner Res 19(5):830–840. doi:10.1359/JBMR.040115
Choi JW, Choe HW, Pai SH (2003) Serum lipid concentrations correlate more strongly with total body fat than with body mass index in obese humans. Clin Chim Acta 329:83–87. doi:10.1016/S0009-8981(03)00018-4
About this article
Cite this article
Sivas, F., Alemdaroğlu, E., Elverici, E. et al. Serum lipid profile: its relationship with osteoporotic vertebrae fractures and bone mineral density in Turkish postmenopausal women. Rheumatol Int 29, 885–890 (2009). https://doi.org/10.1007/s00296-008-0784-4