Skip to main content
SpringerLink
Log in

The protein–creatinine ratio in spot morning urine samples and 24-h urinary protein excretion in patients with systemic lupus erythematosus

  • Original Article
  • Published:
Rheumatology International Aims and scope Submit manuscript

Abstract

A 24-h urinary protein is a standard way to diagnose lupus nephritis. Assessment of protein–creatinine (Pr–Cr) ratio in morning spot urine is a valuable method in diabetic patients but not use in systemic lupus erythematous (SLE) patients routinely. In this study Pr–Cr ratio in spot urine was compare with 24-h urine protein; if they have valuable correlation we can use this test instead of 24-h urinary protein. The aim of this study was to evaluate the correlation of spot urine Pr–Cr ratio for prediction of significant proteinuria (≥300 mg/24 h) in patients with SLE. A cross-section study was conducted in 74 hospitalized women with SLE. The correlation between Pr–Cr in first morning urine specimens and urinary protein excretion in 24-h collections were analyzed. Correlation between Pr–Cr ratio in spot morning urine specimens and urinary protein excretion in 24-h collections was significant (P < 0.0001, r = 0.83). A high correlation and precision of agreement were demonstrated between the two methods of assessment proteinuria in lupus patients. The difference between the two methods was less than the biological variability in the protein excretion and its measurement, enabling the methods to be used interchangeably creatinine ratio in spot morning urine samples is a precise indicator of proteinuria in patients with lupus nephritis and represents a simple and inexpensive procedure in establishing severity of proteinuria in patients with SLE.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. Najafi I (2001) Renal involvement in SLE: systemic lupus erythematous book. Dr Akbarian M: Rheumatology Research Center, pp 178–182

  2. Peterson PL, Karim MY, Abbs IC, Cruz DPD, Hughes GRV (2003) Correlation of 24-hour urinary protein quantification with spot urine albumin:creatinine ratio in screening for renal involvement in systemic lupus erythematosus: a pilot study. Arthritis Rheum 48(9):579

    Google Scholar 

  3. Ruggeneti P, Gaspari F, Perna A, Remuzzi G (1998) Cross sectional longitudinal study of spot morning urine protein:creatinine ratio, 24 hour urine protein excretion rate, glomerular filtration rate, and end stage renal failure in chronic renal disease in patients without diabetes. BMJ 316:504–509

    Google Scholar 

  4. Tamura S, Shimizu T, Kawakatsu H, Tateishi S (2004) Correlation between 24-hour urinary protein excretion and protein/creatinine ratio in the first voided morning urine sample. Nippon Jinzo Gakkai Shi 46(1):26–34

    PubMed  Google Scholar 

  5. Kristal B, Shasha SM, Labin L, Cohen A (1988) Estimation of quantitative proteinuria by using the protein–creatinine ratio in random urine samples. Am J Nephrol 8(3):198–203

    Article  PubMed  CAS  Google Scholar 

  6. Chu NF, Ferng SH, Shieh SD, Fan CD, Shyh TP, Chu PL (1990) Assessment of proteinuria by using the protein/creatinine ratio of single-voided urine. J Formos Med Assoc 89(8):657–660

    PubMed  CAS  Google Scholar 

  7. Christopher–Stine L, Petri M, Astor BC, Fine D (2004) Urine protein-to-creatinine ratio is a reliable measure of proteinuria in lupus nephritis. J Rheumatol 31(8):1557–1559

    PubMed  CAS  Google Scholar 

  8. Neithardt AB, Dooley SL, Borenztajn J (2002) Prediction of 24-hour protein excertion in pregnancy with a single voided urine protein-to-creatinine ratio. Am J Obstet Gynecol 186(5):883–886

    Article  PubMed  CAS  Google Scholar 

  9. Xin G, Wang M, Jiao LL, Xu GB, Wang HY (2004) Protein-to-creatinine ratio in spot urine samples as a predictor of quantitation of proteinuria. Clin Chim Acta 350:35–39

    Article  PubMed  CAS  Google Scholar 

  10. Rodby RA, Rohde Rd, Sharon Z, Pohl MA, Bain RP, Lewis EJ (1995) The urine protein to creatinie ratio as a predictor of 24-hour urine protein excertion in type 1 diabetic patients with nephropathy. The collaborative study group. Am J Kidney Dis 26(6):904–909

    Article  PubMed  CAS  Google Scholar 

  11. Chitalia VC, Kothari J, Welle EJ, Livesey JH, Robson RA, Searle M, Lynn KL (2001) Cost-benefit analysis and prediction of 24-hour proteinuria from the spot urine protein–creatinine ratio. Clin Nephrol 55(6):436–447

    PubMed  CAS  Google Scholar 

  12. Al RA, Baykal C, Karacay O, Geyik PO, Altun S, Dolen I (2004) Random urine protein–creatinine ratio to predict proteinuria in new-onset mild hyper tension in late pregnancy. Obstet Gynecol 104(2):367–371

    PubMed  CAS  Google Scholar 

  13. Yamasmit W, Chaithongwongwathana S, Charoenvidhya D, Uerpairojkit B, Tolosa JE (2004) Random urinary protein-to-creatinine ratio for prediction of significant proteinuria in women with preeclampsia. J Matern Fetal Neonatal Med 16:275–279

    Article  PubMed  CAS  Google Scholar 

  14. Morales JV, Weber R, Wagner MB, Barros EJ (2004) Is morning urinary protein/creatinine ratio a reliable estimator of 24-h proteinuria in patients with glomerulonephritis and different levels of renal function? J Nephrol 17(5):666–672

    PubMed  CAS  Google Scholar 

  15. Munro BH (2005) Statistical methods for health care research. Lippincott Williams & Wilkins

Download references

Author information

Authors and Affiliations

  1. Isfahan University of Medical Science, Isfahan, Iran

    Mansour Salesi, Mansoor Karimifar, Ziba Farajzadegan, Kamal Esalatmanesh, Shahrzad Khosravi, Parvin Fallahi & Mahmood Akbarian

Authors
  1. Mansour Salesi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Mansoor Karimifar
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Ziba Farajzadegan
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Kamal Esalatmanesh
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Shahrzad Khosravi
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Parvin Fallahi
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Mahmood Akbarian
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Mansour Salesi.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Salesi, M., Karimifar, M., Farajzadegan, Z. et al. The protein–creatinine ratio in spot morning urine samples and 24-h urinary protein excretion in patients with systemic lupus erythematosus. Rheumatol Int 29, 503–507 (2009). https://doi.org/10.1007/s00296-008-0742-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00296-008-0742-1

Keywords

Search

Navigation