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Circulating E-selectin and tumor necrosis factor-α in extraarticular involvement and joint disease activity in rheumatoid arthritis

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Abstract

In this cross-sectional study, we assessed the relationship between circulating TNF-α and E-selectin (sE-selectin) with extraarticular involvement and severity of joint disease in RA. We compared 56 patients who had RA and extraarticular involvement (ExRA) with a group of 84 patients with only articular involvement (non-ExRA). ExRA had higher circulating TNF-α than non-ExRA (32 ± 9 vs. 28 ± 6 pg/mL, P = 0.002). sE-selectin levels did not differ between both groups. sE-selectin correlated with tender joint count (rho = 0.19, P = 0.03), morning stiffness (rho = 0.19, P = 0.03), severity of pain (rho = 0.21, P = 0.02), disease activity (assessed by the patient) (rho = 0.21, P = 0.02), HAQ-DI (rho = 0.29, P = 0.004), and rheumatoid factor titers (rho = 0.31, P = <0.001). Circulating TNF-α had no correlation with sE-selectin or disease activity. We concluded that sE-selectin correlated with severity of joint disease, further follow-up studies should evaluate if sE-selectin is useful as prognosis marker for progression of articular damage.

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Acknowledgments

Funding for this project was provided by a grant from the Fondo de Fomento a la Investigación Instituto Mexicano del Seguro Social (IMSS) number: IMSS-2004/034 and 2005/1/I/048.

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Authors and Affiliations

  1. Section of Musculoskeletal Diseases and Autoimmunity, Clinical Epidemiology Research Unit, Instituto Mexicano del Seguro Social (IMSS), Hospital de Especialidades Centro Médico Nacional de Occidente, Belisario Domínguez No. 1000, Col. Independencia, Guadalajara, Mexico

    Esther G. Corona-Sanchez, Mario Salazar-Paramo & Jorge I. Gamez-Nava

  2. Department of Internal Medicine-Rheumatology, Hospital General Regional 110, IMSS, Avenida Circunvalación Oblatos No. 2208, Col. Oblatos, Guadajara, Mexico

    Laura Gonzalez-Lopez, Erika A. Aguilar-Chavez & Carlos Loaiza-Cardenas

  3. Postgraduate Program of Public Health Sciences, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Mexico

    Laura Gonzalez-Lopez & Jorge I. Gamez-Nava

  4. Departamento de Biología Molecular y Genómica, Instituto de Investigación en Reumatología y del Sistema Músculo Esquelético, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada No. 950, Col. Independencia, 44340, Guadalajara, Mexico

    Jose F. Muñoz-Valle, Monica Vazquez-Del Mercado, Edith Oregon-Romero & Rosa E. Navarro-Hernandez

  5. Department of General Internal Medicine, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA

    Maria A. Lopez-Olivo

  6. Salto del Agua 2192, Col. Jardines del Country, 44210, Guadalajara, Jalisco, Mexico

    Jorge I. Gamez-Nava

Authors
  1. Esther G. Corona-Sanchez
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  2. Laura Gonzalez-Lopez
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  3. Jose F. Muñoz-Valle
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  4. Monica Vazquez-Del Mercado
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  5. Maria A. Lopez-Olivo
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  6. Erika A. Aguilar-Chavez
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  7. Mario Salazar-Paramo
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  8. Carlos Loaiza-Cardenas
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  9. Edith Oregon-Romero
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  10. Rosa E. Navarro-Hernandez
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  11. Jorge I. Gamez-Nava
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Corresponding author

Correspondence to Jorge I. Gamez-Nava.

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Corona-Sanchez, E.G., Gonzalez-Lopez, L., Muñoz-Valle, J.F. et al. Circulating E-selectin and tumor necrosis factor-α in extraarticular involvement and joint disease activity in rheumatoid arthritis. Rheumatol Int 29, 281–286 (2009). https://doi.org/10.1007/s00296-008-0688-3

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  • DOI: https://doi.org/10.1007/s00296-008-0688-3

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