Skip to main content

Advertisement

SpringerLink
Log in

Musculoskeletal affections among kidney recipients: prevalence and risk predictors

  • Original Article
  • Published:
Rheumatology International Aims and scope Submit manuscript

Abstract

The population of kidney recipients (KR) is steadily increasing in Mansoura and more than 1,800 operations were completed. The extent of musculoskeletal affections (MSA) in this population is not fully known. The purpose of this study is to determine MSA in this KR population and find possible risk predictors. Randomly selected KR (n = 117) were subjected to joint examination, joint pain and morbidity measurements and bone mineral density (BMD) estimation. Laboratory measurements included biochemical, haematological and serological variables. The majority of KR (81.2%) were complaining/suffering from MSA. These included bone loss (n = 78), joint pain (n = 63), skeletal muscle affection (n = 21), soft tissue affection (n = 25), and leg bone pain syndrome (n = 7). Serum creatinine and hepatitis PCR serology demonstrated a significant difference (P < 0.05) between KR with MSA and KR without MSA. Negative hepatitis PCR serology was the only significant (P < 0.05) risk predictor for MSA in this population of KR. This study identified MSA in this steadily increasing KR population. That hepatitis infection was a negative risk predictor for MSA in this KR population warrants further studies.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. Llach F, Bover J (2000) Renal osteodystrophy. In: Brenner BM (ed) The kidney, vol 2, 6th edn. WB Saunders Company, Philadelphia, pp 2103–2186

  2. Lukert BP, Kream BE (1996) Clinical and basic aspects of glucocorticoid action in bone. In: Bilezikian JP, Raisz LG, Rodan GA (eds) Principles of bone biology. Academic Press, New York, pp 533–548

    Google Scholar 

  3. Stein B, Halloran BP, Reinhardt T, Engstrom GW, Bales CW, Drezner MK, Currie KL, Takizawa M, Adams JS, Epstein S (1991) Cyclosporine A increases synthesis of 1, 25 dihydroxyvitamin D3 in the rat and mouse. Endocrinology 128:1369–1373

    Article  PubMed  CAS  Google Scholar 

  4. Pichette V, Bonnardeaux A, Prudhomme L, Gagne M, Cardicnal J, Ouimer D (1996) Long-term bone loss in kidney transplant recipients: a cross-sectional and longitudinal study. Am J Kidney Dis 28:105–111

    Article  PubMed  CAS  Google Scholar 

  5. Kart-Koseoglu H, Yucel AE, Isiklar I, Tuker I, Akcali Z, Haberal M (2003) Joint pain and arthritis in renal transplant recipients and correlation with cyclosporine therapy. Rheumatol Int 23:159–162

    Article  PubMed  CAS  Google Scholar 

  6. Ducloux D, Schuller V, Bresson-Vautrin C, Chalopin JM (1997) Colchicine myopathy in renal transplant recipients on cyclosporine. Nephrol Dial Transplant 12:2389–2392

    Article  PubMed  CAS  Google Scholar 

  7. Goffin E, vande Berg B, Pirson Y, Malghem J, Maldague B, van Ypersele De Strihou C (1993) Epiphyseal impaction as a cause of severe osteoarticular pain of lower limbs after renal transplantation. Kidney Int 44:98–106

  8. Mc Rae R (2004) Clinical orthopaedic examination, 5th edn. Churchill livings tone, London

  9. Buchner A, Erdfelder E, Paul F How to use Gpower. http://www.psycho.uni-duesseldorf.de/aap/projects/gpower/index.html

  10. Frost ML, Blake GM, Fogelman I (2001) Quantitative ultrasound and bone mineral density are equally strongly associated with risk factors for osteoporosis. J Bone Miner Res 16:406–416

    Article  PubMed  CAS  Google Scholar 

  11. Hartl F, Tyndall A, Kraenzlin M, Bachmeier C, Guckel C, Senn U, Hans D, Theiler R (2002) Discriminatory ability of quantitative ultrasound parameters and bone mineral density in a population-based sample of post-menopausal women with vertebral fracture: results of the Basel Osteoporosis Study. J Bone Miner Res 17:321–330

    Article  PubMed  CAS  Google Scholar 

  12. Mondry A, Hetzel GR, Willers R, Feldkamp J, Grabensee B (2001) Quantitative heel ultrasound in assessment of bone structure in renal transplant recipients. Am J Kidney Dis 37:932–937

    Article  PubMed  CAS  Google Scholar 

  13. Kosch M, Hausberg M, Link T, Kemkes M, Barenbrock M, Dietl KH, Matzkies F, Rahn KH, Kisters K (2000) Measurement of skeletal status after renal transplantation by quantitative ultrasound. Clin Nephrol 54:15–21

    PubMed  CAS  Google Scholar 

  14. El-Husseini AA, El-Agroudy AE, Wafa EW, Mohsen T, Sobh MA, Ghoneim MA (2004) Bone mineral density in live related kidney transplant children and adolescents. Int Urol Nephrol 36:95–100

    Article  PubMed  Google Scholar 

  15. Carlini RG, Rojas E, Weisinger JR, Lopez M, Martinis R, Arminio A, Belloin-front E (2000) Bone disease in patients with long-term renal transplantation and normal renal function. Am J Kidney Dis 36:160–166

    Article  PubMed  CAS  Google Scholar 

  16. Cayco AV, Wysolmerski J, Simpson C, Mitnick MA, Gundberg C, Kliger A, Lorber M, Silver D, Basadonna G, Friedman A, Insogna K, Cruz D, Bia M (2000) Posttransplant bone disease: evidence for a high bone resorption state. Transplantation 70:1722–1728

    Article  PubMed  CAS  Google Scholar 

  17. Mikuls TR, Julian BA, Bartolucci A, Saag KG (2003) Bone mineral density changes within six months of renal transplantation. Transplantation 75:49–54

    Article  PubMed  CAS  Google Scholar 

  18. Roe SD, Porter CJ, Godber IM, Hoking DJ, Cassidy MJ (2005) Reduced bone mineral density in male renal transplant recipients: evidence of persisting hyperparathyroidism. Osteoporosis Int 16:142–148

    Article  Google Scholar 

  19. Bailie GR, Eisele G (1990) Cyclosporine-associated arthralgia. Clin Nephrol 33:256–257

    PubMed  CAS  Google Scholar 

  20. Dubost JJ, Fourcade J, Sourbrier M, Ristori JM, Sauvezie B, Deteix P (1997) Epiphyseal pain from cyclosporine in renal transplants. Nephrologie 18:22

    Google Scholar 

  21. Jagose JT, Bailey RR, Hughes TH (1997) Acute bone-marrow oedema in cyclosporine-treated renal transplant recipients. Q J Med 90:359–366

    CAS  Google Scholar 

  22. Goffin E, Vande Berg B, Devogelaer JP, Pochet JM, De Meyer M, Squifflet JP, Pirson Y (2003) Post-renal transplant syndrome of transient lower limb joint pain: description under a tacrolimus-based immunosuppression. Clin Nephrol 59:98–105

    PubMed  CAS  Google Scholar 

  23. Franco M, Blaimont A, Albano L, Bendini C, Cassuto E, Jaeger P (2004) Tacrolimus pain syndrome in renal transplant patients: report of two cases. Joint Bone Spine 71:157–159

    Article  PubMed  Google Scholar 

  24. Kahl L, Medsger TA Jr (1986) Severe arthralgias after wide fluctuation in corticosteroid dosage. J Rheumatol 13:1063–1065

    PubMed  CAS  Google Scholar 

  25. de Boer AG, van Lanschot JJ, Stalmeier PF, van Sandick JW, Hulscher JB, de Haes JC, Sprangers MA (2004) Is a single-item visual analogue scale as valid, reliable and responsive as multi-item scales in measuring quality of life? Qual life Res 13:311–320

    Article  PubMed  Google Scholar 

  26. Ahonen RE (1980) Striated muscle ultrastructure in uremic patients and in renal transplant recipients. Acta Neuropathol (Berl) 50:163–166

    Article  CAS  Google Scholar 

  27. Naredo Sanchez E, Balsa Criado A, Sanz Guajardo A, Pantoja Zatza L, Martin Mola E, Gijon Banos J (1994) Leg bone pain syndrome due to cyclosporine in a renal transplant patient. Clin Exp Rheumatol 12:653–656

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Rheumatology and Rehabilitation, University of Mansoura, Mansoura, Egypt

    Alia M. Atallah, Seif M. Farag & Mohamed K. Senna

  2. Urology and Nephrology Center, University of Mansoura, Mansoura, Egypt

    Mohamed A. Ghoneim

Authors
  1. Alia M. Atallah
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Seif M. Farag
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Mohamed K. Senna
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Mohamed A. Ghoneim
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Alia M. Atallah.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Atallah, A.M., Farag, S.M., Senna, M.K. et al. Musculoskeletal affections among kidney recipients: prevalence and risk predictors. Rheumatol Int 28, 1085–1090 (2008). https://doi.org/10.1007/s00296-008-0585-9

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00296-008-0585-9

Keywords

Search

Navigation