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Infection of an urachal cyst during etanercept therapy in juvenile idiopathic arthritis

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Abstract

Etanercept, a tumor necrosis factor (TNF) receptor alpha antagonist is licensed for the treatment in patients affected by polyarticular juvenile idiopathic arthritis, who do not tolerate or had an inadequate response to methotrexate. Infections related to immunosuppression by etanercept are of major concern. We report on a 17-year-old boy with enthesitis-related arthritis who developed a major infection of an urachal cyst 18 months after initiation of etanercept therapy, which required surgery. The urachus had not been symptomatic before.

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Abbreviations

MTX:

Methotrexate

TNF:

Tumor necrosis factor

MRI:

Magnetic resonance imaging

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Authors and Affiliations

  1. Children’s Hospital, Section of Pediatric Rheumatology, Immunology and Infectious Diseases, University of Wuerzburg, Josef-Schneider-Str. 2, 97090, Wuerzburg, Germany

    A. Holl-Wieden & H. J. Girschick

  2. Department of Radiology, Section of Pediatric Radiology, University of Wuerzburg, Wuerzburg, Germany

    M. Beer

  3. Institute of Pathology, University of Wuerzburg, Wuerzburg, Germany

    A. Marx

  4. Department of Urology, University of Wuerzburg, Wuerzburg, Germany

    R. Bonfig

  5. Institute of Hygiene and Microbiology, University of Wuerzburg, Wuerzburg, Germany

    D. Tappe

Authors
  1. A. Holl-Wieden
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  2. M. Beer
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  3. A. Marx
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  4. R. Bonfig
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  5. D. Tappe
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  6. H. J. Girschick
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Corresponding author

Correspondence to H. J. Girschick.

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Holl-Wieden, A., Beer, M., Marx, A. et al. Infection of an urachal cyst during etanercept therapy in juvenile idiopathic arthritis. Rheumatol Int 28, 819–822 (2008). https://doi.org/10.1007/s00296-008-0521-z

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  • DOI: https://doi.org/10.1007/s00296-008-0521-z

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