Skip to main content

Frequency of HLA-B27 and its alleles in patients with Reiter syndrome: comparison with the frequency in other spondyloarthropathies and a healthy control population


This retrospective study analyzed the HLA-B*27 alleles in a group of 20 consecutive patients with the diagnosis of Reiter syndrome (RS) followed in a tertiary referral university hospital in Brazil, during the period 1990–2006, and compared the data with that observed in other patients with spondyloarthropathies followed at the same institution. Eight cases were associated to gastrointestinal infection, eight cases to previous urethritis, and four cases presented no established preceding infection. HLA-B*27 alleles were typed by polymerase chain reaction-amplified DNA hybridized with sequence-specific oligonucleotide probes (HLA-B*2701 to HLA-B*2721). They were compared to a group of 108 patients with ankylosing spondylitis (AS), 40 with undifferentiated spondyloarthropathy (uSpA) and 111 healthy controls. Among the 20 patients, 17 were HLA-B*27 positive (85%). Two HLA-B*27 alleles were observed: HLA-B*2705 (65%) and HLA-B*2702 (35%). In the other spondyloarthropathies, the observed alleles were HLA-B*2705 (90% in AS and 92.5% in uSpA), HLA-B*2702 (8% in AS and 5% in uSpA), HLA-B*2704 (1% in AS and 2.5% in uSpA) and HLA-B*2713 (1% in AS). Among the 111 healthy controls, 80% presented HLA-B*2705, followed by HLA-B*2702 in 10%, HLA-B*2703 in 6%, HLA-B*2707 in 3% and HLA-B*2713 in 1%. Concluding, in the HLA-B*27 positive patients with RS in this study there was predominance of HLA-B*2705 allele, in a lower frequency than that observed in patients with other spondyloarthropathies and healthy controls.

This is a preview of subscription content, access via your institution.


  1. 1.

    Reiter H (1916) Uber eine bisher unerkannte Spirochäten infection. DMW 42:1535–1536

    Google Scholar 

  2. 2.

    Fiessinger N, Leroy E (1916) Contribution à l´étude d´une épidémie de dysenterie dans la Somme. Bull Mem Soc Med Hop Paris 40:2030–2069

    Google Scholar 

  3. 3.

    Moll JMH, Haslock I, Macrae IF et al (1974) Association between spondylitis, psoriatic arthritis, Reiter’s disease, the intestinal arthropathies and Behcet’s syndrome. Medicine (Baltimore) 53:343–364

    Article  CAS  Google Scholar 

  4. 4.

    Aho K, Ahvonen P, Lassus A et al (1974) HLA B27 in reactive arthritis. A study of Yersinia arthritis and Reiter’s disease. Arthritis Rheum 17:521–526

    PubMed  Article  CAS  Google Scholar 

  5. 5.

    Michet CJ, Machado EBV, Ballard DJ, McKenna CH (1988) Epidemiology of Reiter’s syndrome in Rochester, Minnesota 1950–1980. Arthritis Rheum 31:428–432

    PubMed  Article  CAS  Google Scholar 

  6. 6.

    Thomson GTD, De Rubeis DA, Hodge MA et al (1995) Post-Salmonella reactive arthritis: late clinical sequelae in a point source cohort. Am J Med 98:13–21

    PubMed  Article  CAS  Google Scholar 

  7. 7.

    Iliopoulos A, Karras D, Ioakimidis D et al (1995) Change in the epidemiology of Reiter’s syndrome (reactive arthritis) in the post-AIDS era? An analysis of cases appearing in the Greek army. J Rheumatol 22:252–254

    PubMed  CAS  Google Scholar 

  8. 8.

    Leirisalo M, Skylv G, Kousa M et al (1982) Followup study of patients with Reiter’s disease and reactive arthritis, with special reference to HLA-B27. Arthritis Rheum 25:249–259

    PubMed  Article  CAS  Google Scholar 

  9. 9.

    Arnett FC, Hochberg MC, Bias WB (1977) Cross-reactive HLA antigens in B27-negative Reiter’s syndrome and sacroiliitis. Johns Hopkins Med J 141:193–197

    PubMed  Google Scholar 

  10. 10.

    Ben-Chetrit E, Brautbar C, Rubinow A (1985) HLA antigens in Reiter’s syndrome in Israeli patients. J Rheumatol 12:964–966

    PubMed  CAS  Google Scholar 

  11. 11.

    Stein M, Davis P, Emmanuel J, West G (1990) The spondyloarthropathies in Zimbabwe: a clinical and immunologic profile. J Rheumatol 17:1337–1339

    PubMed  CAS  Google Scholar 

  12. 12.

    Keat A (1983) Reiter’s syndrome and reactive arthritis in perspective. N Engl J Med 309:1606–1615

    PubMed  CAS  Article  Google Scholar 

  13. 13.

    Cuttica RJ, Scheines EJ, Garay SM, Romanelli MDC, Maldonado-Cocco JA (1992) Juvenile onset Reiter’s syndrome. A retrospective study of 26 patients. Clin Exp Rheumatol 10:285–288

    PubMed  CAS  Google Scholar 

  14. 14.

    Butler M, Russell AS, Percy JS, Lentle BC (1979) A follow-up study of 48 patients with Reiter’s syndrome. Am J Med 67:868–870

    Article  Google Scholar 

  15. 15.

    Sampaio-Barros PD, Conde RA, Donadi EA et al (2003) Undifferentiated spondyloarthropathies in Brazilians: importance of HLA-B27 and the B7-CREG alleles in characterization and disease progression. J Rheumatol 30:2632–2637

    PubMed  CAS  Google Scholar 

  16. 16.

    Sampaio-Barros PD, Bertolo MB, Kraemer MHS, Marques Neto JF, Samara AM (2001) Primary ankylosing spondylitis: patterns of disease in a Brazilian population of 147 patients. J Rheumatol 28:560–565

    PubMed  CAS  Google Scholar 

  17. 17.

    Conde RA, Sampaio-Barros PD, Donadi EA et al (2003) Frequency of the HLA-B27 alleles in Brazilian patients with ankylosing spondylitis. J Rheumatol 30:2511–2512

    Google Scholar 

  18. 18.

    Reveille JD, Ball EJ, Khan MA (2001) HLA-B27 and genetic predisposing factors in spondyloarthropathies. Curr Opin Rheumatol 13:265–272

    PubMed  Article  CAS  Google Scholar 

  19. 19.

    Sampaio-Barros PD, Conde RA, Bonfiglioli R, Bertolo MB, Samara AM (2006) Characterization and outcome of uveitis in 350 patients with spondyloarthropathies. Rheumatol Int 26:1143–1146

    PubMed  Article  Google Scholar 

Download references

Author information



Corresponding author

Correspondence to Percival D. Sampaio-Barros.

Additional information

This work was supported by the Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP).

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Sampaio-Barros, P.D., Conde, R.A., Donadi, E.A. et al. Frequency of HLA-B27 and its alleles in patients with Reiter syndrome: comparison with the frequency in other spondyloarthropathies and a healthy control population. Rheumatol Int 28, 483–486 (2008).

Download citation


  • Reiter syndrome
  • HLA-B27
  • Epidemiology