Abstract
The authors describe a young man suffering from systemic sclerosis who showed a dramatic progression of skin involvement after the appearance of anti-Scl70 antibody.
References
Derk CT, Jimenez SA (2003) Systemic sclerosis: current view of its pathogenesis. Autoimmun Rev 2:181–191
Walker UA, Tyndall A, Czirjak L, Denton C., Farge-Bancel D, Kowal-Bielecka O, Muller-Ladner U, Bocelli-Tyndall C, Matucci-Cerinic M and EUSTAR Co-authors (2007) Clinical risk assessment of organ manifestations in systemic sclerosis—a report from the EULAR Scleroderma Trials and Research (EUSTAR) group data base. Ann Rheum Dis 66:754–763
Jacobsen S, Ullman S, Shen GQ, Wiik A, Haberq P (2001) Influence of clinical features, serum antinuclear antibodies, and lung function on survival of patients with systemic sclerosis. J Rheumatol 28:2454–2459
Diot E, Giraudeau B, Diot P, Degenee D, Ritz L, Guilmot JL, Lemarie E (1999) Is anti-topoisomerase I a serum marker of pulmonary involvement in systemic sclerosis? Chest 116:715–720
Steen VD (2005) Autoantibodies in systemic sclerosis. Seminars Arthritis Rheum 35:35–42
Cutolo M, Pizzorni C, Tuccio M, Burroni A, Craviotto C, Basso M, Seriolo B, Sulli A (2004) Nailfold videocapillaroscopic patterns and serum autoantibodies in systemic sclerosis. Rheumatology 43:719–726
Hu PQ, Fertig N, Medsger TA Jr, Wright TM (2003) Correlation of serum anti-DNA topoisomerase I antibody levels with disease severity and activity in systemic sclerosis. Arthritis Rheum 48:1363–1373
Hénault J, Tremblay M, Clément I, Raymond Y, Senécal Y (2004) DNA binding of anti-DNA topoisomerase I autoantibodies to the cell surface of fibroblasts in patients with systemic sclerosis. Arthritis Rheum 50:3265–3274
Hénault J, Robtaille G, Senécal Y (2006) DNA topoisomerase I binding to fibroblasts induces monocyte adhesion and activation in the presence of anti-topoisomerase I antibodies from systemic sclerosis patients. Arthritis Rheum 54:963–973
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Caramaschi, P., Volpe, A., Carletto, A. et al. Dramatic progression of skin involvement in systemic sclerosis after the appearance of anti-Scl70 antibody: a case report. Rheumatol Int 28, 385–386 (2008). https://doi.org/10.1007/s00296-007-0434-2
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00296-007-0434-2