Skip to main content

Bone mineral density is not related to severity of osteoarthritis in the knee in postmenopausal women

Abstract

Although some studies have suggested that osteoporosis and osteoarthritis are inversely related in epidemiologic terms, a spectrum of relations between the two diseases has been described in this study. In 95 postmenopausal women (mean age 64.4 ± 8.49 years, range 49–83 years), we investigated the relation between bone mineral density (BMD) in the femoral neck and lumbar vertebrae (L2–L4) and osteoarthritis in the knee. BMD was measured with dual X-ray absorptiometry. Osteoarthritis was evaluated with anterior–posterior weight-bearing radiographs with the knee in extension, and these were graded for severity on a 5-point scale according to the Kellgren–Lawrence criteria. We found no clear statistical relation between BMD in the femoral neck or lumbar vertebrae and osteoarthritis in the knee. Given that some studies have found BMD to be significantly higher in patients with osteoarthritis, the lack of such relation in our patients may be due to environmental and/or genetic factors.

This is a preview of subscription content, access via your institution.

References

  1. Bayramoglu M, Sozay S, Karatas M, Kilinc S (2005) Relationships between muscle strength and bone mineral density of three body regions in sedentary postmenopausal women. Rheumatol Int 25:513–517

    PubMed  Article  Google Scholar 

  2. Sambrook P, Cooper C (2006) Osteoporosis. Lancet 367:2010–2018

    PubMed  Article  CAS  Google Scholar 

  3. Sambrook P, Naganathan V (1997) What is the relationship between osteoarthritis and osteoporosis? Baillieres Clin Rheumatol 11:695–710

    PubMed  Article  CAS  Google Scholar 

  4. Cicuttini F, Wluka A, Davis S, Strauss BJ, Yeung S, Ebeling PR (2004) Association between knee cartilage volume and bone mineral density in older adults without osteoarthritis. Rheumatology 43:765–769

    PubMed  Article  CAS  Google Scholar 

  5. Bakker AD, Klein-Nulend J, Tanck E, Heyligers IC, Albers GH, Lips P, Burger EH (2006) Different responsiveness to mechanical stress of bone cells from osteoporotic versus osteoarthritic donors. Osteoporos Int 17:827–833

    PubMed  Article  CAS  Google Scholar 

  6. Foss MV, Byers PD (1972) Bone density, osteoarthrosis of the hip, and fracture of the upper end of the femur. Ann Rheum Dis 31:259–264

    PubMed  CAS  Google Scholar 

  7. Antoniades L, MacGregor AJ, Matson M, Spector TD (2000) A cotwin control study of the relationship between hip osteoarthritis and bone mineral density. Arthritis Rheum 43:1450–1455

    PubMed  Article  CAS  Google Scholar 

  8. Belmonte-Serrano MA, Bloch DA, Lane NE, Michel BE, Fries JF (1993) The relationship between spinal and peripheral osteoarthritis and bone density measurements. J Rheumatol 20:1005–1013

    PubMed  CAS  Google Scholar 

  9. Hannan MT, Anderson JJ, Zhang Y, Levy D, Felson DT (1993) Bone mineral density and knee osteoarthritis in elderly men and women. The Framingham study. Arthritis Rheum 36:1671–1680

    PubMed  Article  CAS  Google Scholar 

  10. Hart DJ, Mootoosamy I, Doyle DV, Spector TD (1994) The relationship between osteoarthritis and osteoporosis in the general population: the Chingford study. Ann Rheum Dis 53:158–162

    PubMed  CAS  Google Scholar 

  11. Sowers M, Lachance L, Jamadar D, Hochberg MC, Hollis B, Crutchfield M, Jannausch ML (1999) The associations of bone mineral density and bone turnover markers with osteoarthritis of the hand and knee in pre- and perimenopausal women. Arthritis Rheum 42:483–489

    PubMed  Article  CAS  Google Scholar 

  12. Verstraeten A, Van Ermen H, Haghebaert G, Nijs J, Geusens P, Dequeker J (1991) Osteoarthrosis retards the development of osteoporosis. Observation of the coexistence of osteoarthrosis and osteoporosis. Clin Orthop Relat Res 264:169–177

    PubMed  Google Scholar 

  13. Weintroub S, Papo J, Ashkenazi M, Tardiman R, Weissman SL, Salama R (1982) Osteoarthritis of the hip and fracture of the proximal end of the femur. Acta Orthop Scand 53:261–264

    PubMed  CAS  Article  Google Scholar 

  14. Yokozeki H, Igarashi M, Karube S, Shiraki M, Kurokawa T (1995) The relation between osteoporosis of the spine and osteoarthritis of the knee. A study using dual energy X-ray absorptiometry and radiographs. Int Orthop 19:282–284

    PubMed  Article  CAS  Google Scholar 

  15. Burr DB, Martin RB, Schaffler MB, Jurmain RD, Harner EJ, Radin EL (1983) Osteoarthrosis: sex-specific relationship to osteoporosis. Am J Phys Anthropol 61:299–303

    PubMed  Article  CAS  Google Scholar 

  16. Terauchi M, Shirakura K, Katayama M, Higuchi H, Takagishi K (1998) The influence of osteoporosis on varus osteoarthritis of the knee. J Bone Joint Surg Br 80:432–436

    PubMed  Article  CAS  Google Scholar 

  17. Yahata Y, Aoyagi K, Yoshida S, Ross PD, Yoshimi I, Moji K, Takemoto T (2002) Appendicular bone mass and knee and hand osteoarthritis in Japanese women: a cross-sectional study. BMC Musculoskelet Disord 3:24

    PubMed  Article  Google Scholar 

  18. Kellgren JK, Lawrence JS (1957) Radiological assessment of osteo-arthrosis. Ann Rheum Dis16:494–502

    Google Scholar 

  19. Glowacki J, Hurwitz S, Thornhill TS, Kelly M, LeBoff MS (2003) Osteoporosis and vitamin-D deficiency among postmenopausal women with osteoarthritis undergoing total hip arthroplasty. J Bone Joint Surg Am 85-A 12:2371–2377

    Google Scholar 

  20. Dequeker J, Mohan S, Finkelman RD, Aerssens J, Baylink DJ (1993) Generalized osteoarthritis associated with increased insulin-like growth factor types I and II and transforming growth factor beta in cortical bone from the iliac crest. Possible mechanism of increased bone density and protection against osteoporosis. Arthritis Rheum 36:1702–1708

    PubMed  Article  CAS  Google Scholar 

  21. Celiker R, Arslan S (2000) Comparison of serum insulin-like growth factor-1 and growth hormone levels in osteoporotic and non-osteoporotic postmenopausal women. Rheumatol Int 19:205–208

    PubMed  Article  CAS  Google Scholar 

  22. Hulet C, Sabatier JP, Souquet D, Locker B, Marcelli C, Vielpeau C (2002) Distribution of bone mineral density at the proximal tibia in knee osteoarthritis. Calcif Tissue Int 71:315–322

    PubMed  Article  CAS  Google Scholar 

  23. Nevitt MC, Cummings SR, Lane NE, Hochberg MC, Scott JC, Pressman AR, Genant HK, Cauley JA (1996) Association of estrogen replacement therapy with the risk of osteoarthritis of the hip in elderly white women. Study of osteoporotic fractures research group. Arch Intern Med 156:2073–2080

    PubMed  Article  CAS  Google Scholar 

  24. Bettica P, Cline G, Hart DJ, Meyer J, Spector TD (2002) Evidence for increased bone resorption in patients with progressive knee osteoarthritis: longitudinal results from the Chingford study. Arthritis Rheum 46:3178–3184

    PubMed  Article  Google Scholar 

  25. Keen RW, Hart DJ, Lanchbury JS, Spector TD (1997) Association of early osteoarthritis of the knee with a Taq I polymorphism of the vitamin D receptor gene. Arthritis Rheum 40:1444–1449

    PubMed  Article  CAS  Google Scholar 

  26. Morrison NA, Qi JC, Tokita A, Kelly PJ, Crofts L, Nguyen TV, Sambrook PN, Eisman JA (1994) Prediction of bone density from vitamin D receptor alleles. Nature 367:284–287

    PubMed  Article  CAS  Google Scholar 

  27. Cooper C, McAlindon T, Coggon D, Egger P, Dieppe P (1994) Occupational activity and osteoarthritis of the knee. Ann Rheum Dis 53:90–93

    PubMed  CAS  Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Hakan Atalar.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Atalar, H., Yanik, B., Ozcakar, B. et al. Bone mineral density is not related to severity of osteoarthritis in the knee in postmenopausal women. Rheumatol Int 28, 233–236 (2008). https://doi.org/10.1007/s00296-007-0416-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00296-007-0416-4

Keywords

  • Bone density
  • Knee
  • Osteoarthritis
  • Osteoporosis
  • Postmenopause