Rheumatology International

, Volume 27, Issue 9, pp 853–857 | Cite as

Ocular surface and intraocular inflammation are related in SS-I and rheumatoid arthritis patients

  • Mauro CelliniEmail author
  • Piera Versura
  • Pietro Leonetti
  • Marilena Frigato
  • Elena Manfredini
  • Nazzarena Malavolta
  • Emilio C. Campos
Original Article


The purpose of this study is to evaluate the intraocular inflammation at a sub clinical level, in patients suffering from Sjogren’s syndrome (SS-I) and Rheumatoid Arthritis (RA), to relate it with the ocular surface status and to verify the diagnostic performance of the method. Twenty-eight patients suffering from SS-I, 31 patients suffering from RA and 31 normal subjects matched in age and gender were included in the study. A Kowa 500F laser cell flare meter was utilized to quantify the aqueous cells and flare in vivo, ocular surface inflammation was graded by conjunctival cytology and dosage of serum albumin in tears, eye dryness was scored with Tear Function Index. All data resulted significantly different in both SS-I and RA patients vs. control group and also different comparing SS-I vs. RA patients group, except for the Flare values. A blood-aqueous barrier breakdown occurs either in SS-I and RA patients; the degree of the damage is related with ocular surface inflammation and dryness. We recommend the aqueous flare be analysed in those rheumatic patients where an ocular surface inflammation has been documented.


Sjogren’s syndrome Rheumatoid arthritis Laser cell flare Uveitis Inflammation 


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Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • Mauro Cellini
    • 1
    Email author
  • Piera Versura
    • 1
  • Pietro Leonetti
    • 1
  • Marilena Frigato
    • 2
  • Elena Manfredini
    • 2
  • Nazzarena Malavolta
    • 2
  • Emilio C. Campos
    • 1
  1. 1.Department of Surgical Science and Transplants, Sect. OphthalmologyAlma Mater Studiorum Università di BolognaBolognaItaly
  2. 2.Department of Internal Medicine and Aging, Sect. Rheumatology, Azienda Ospedaliera di Bologna, Post-graduate School in RheumatologyUniversity of BolognaBolognaItaly

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