Rheumatology International

, Volume 27, Issue 9, pp 819–825 | Cite as

Nitric oxide levels and the severity of juvenile idiopathic arthritis

  • Blanca Elena R. G. Bica
  • Niele M. Gomes
  • Patrícia D. Fernandes
  • Ronir R. Luiz
  • Vera Lúcia G. KoatzEmail author
Original Article


In this study, we evaluate the distribution of nitric oxide (NO) in the serum of juvenile idiopathic arthritis (JIA) patients, correlating it with parameters of the severity of the disease. Ninety-seven patients with mean age 11.7 years and disease duration 4.8 years, showing active disease or not, grouped as oligoarticular (n = 34), polyarticular (n = 29) and systemic (n = 34) group, presenting uveitis and positive RF with erosive arthritis or active disease and erosions had significantly high levels of NO than the inactive ones. NO correlated with TNF-α in the oligoarticular subtype (P < 0.03), with pain in the polyarticular subtype with active disease (P < 0.04) and with ESR in the systemic subtype with active disease (P < 0.03). TNF-α concentration was high in all patients with active disease, accompanying NO production. The data confirm the production of NO in JIA patients, indicating a possible positive correlation between the production of NO and severity of the disease.


Nitric oxide Juvenile idiopathic arthritis Uveitis 



We would like to thank Dr. Martha Sorenson for the careful assistance with the manuscript. This work was supported by the Brazilian agencies: FAPERJ, FUJB, CNPq.


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Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • Blanca Elena R. G. Bica
    • 1
    • 4
  • Niele M. Gomes
    • 2
  • Patrícia D. Fernandes
    • 2
  • Ronir R. Luiz
    • 3
  • Vera Lúcia G. Koatz
    • 4
    Email author
  1. 1.Clínica de Reumatologia, Hospital Universitário Clementino Fraga FilhoUniversidade Federal do Rio de JaneiroRio de JaneiroBrazil
  2. 2.Departamento de FarmacologiaUniversidade Federal do Rio de JaneiroRio de JaneiroBrazil
  3. 3.NESCUniversidade Federal do Rio de JaneiroRio de JaneiroBrazil
  4. 4.Instituto de Bioquímica MédicaUniversidade Federal do Rio de JaneiroRio de JaneiroBrazil

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