Genotypic analysis of Asp299Gly and Thr399Ile polymorphism of Toll-like receptor 4 in systemic autoimmune diseases of Korean population
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Systemic autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus are mainly characterized by chronic inflammation amplified by large quantities of proinflammatory cytokines released from immune cells including macrophages and dendritic cells. Although the pathogenesis of autoimmune diseases are largely unknown, adaptive immune responses in various systemic autoimmune diseases can be driven by innate immune system as exemplified in pathogenic autoantibody production triggered by infectious agents in the pathogenesis of rheumatoid arthritis and systemic lupus erythematosus [1, 2]. Toll-like receptors (TLRs) are phylogenetically conserved receptors expressed on various cells, mainly on macrophages and dendritic cells that recognize pathogen-associated molecular patterns and are key players in cellular innate immunity with an emerging role as a bridge between innate and adaptive immune responses . TLRs, especially TLR4, are predominantly activated...
KeywordsSystemic Lupus Erythematosus Hyaluronic Acid Mutant Allele Korean Population Systemic Autoimmune Disease
This work has been supported by the Ewha Womans University Research Grant of 2004.
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