Rheumatology International

, Volume 27, Issue 9, pp 887–889 | Cite as

Genotypic analysis of Asp299Gly and Thr399Ile polymorphism of Toll-like receptor 4 in systemic autoimmune diseases of Korean population

  • Eun-Suk KangEmail author
  • Jisoo Lee
Letter to the Editor

Dear Editor,

Systemic autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus are mainly characterized by chronic inflammation amplified by large quantities of proinflammatory cytokines released from immune cells including macrophages and dendritic cells. Although the pathogenesis of autoimmune diseases are largely unknown, adaptive immune responses in various systemic autoimmune diseases can be driven by innate immune system as exemplified in pathogenic autoantibody production triggered by infectious agents in the pathogenesis of rheumatoid arthritis and systemic lupus erythematosus [1, 2]. Toll-like receptors (TLRs) are phylogenetically conserved receptors expressed on various cells, mainly on macrophages and dendritic cells that recognize pathogen-associated molecular patterns and are key players in cellular innate immunity with an emerging role as a bridge between innate and adaptive immune responses [3]. TLRs, especially TLR4, are predominantly activated...


Systemic Lupus Erythematosus Hyaluronic Acid Mutant Allele Korean Population Systemic Autoimmune Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This work has been supported by the Ewha Womans University Research Grant of 2004.


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Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  1. 1.Division of Diagnostic Immunology, Department of Laboratory Medicine, Ewha Womans University Mokdong Hospital, College of MedicineEwha Womans UniversitySeoulSouth Korea
  2. 2.Department of Laboratory Medicine, Samsung Medical Center, School of MedicineSungKyunKwan UniversitySeoulSouth Korea
  3. 3.Division of Rheumatology, Department of Internal Medicine, Ewha Womans University Mokdong Hospital, College of MedicineEwha Womans UniversitySeoulSouth Korea

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