The association between hyperuricemia and the Trp64Arg polymorphism of the beta-3 adrenergic receptor

  • Young Hee Rho
  • Seong Jae Choi
  • Young Ho Lee
  • Jong Dae Ji
  • Gwan Gyu SongEmail author
Original Article


The object of this study was to determine the association of Trp64Arg polymorphism with hyperuricemia. This study is an age-matched, case-controlled study of 203 hyperuricemic and 203 normouricemic men. The frequency of genotypes was compared between the two groups. Possible confounding metabolic variables were included in a multiple logistic regression model for multivariate adjustment. The genotype frequencies of Trp64Trp, Trp64Arg, and Arg64Arg in hyperuricemic and normouricemic groups are respectively 130, 69, and 4 (64.0%, 34.0%, 2.0%) and 154, 45, and 4 (75.9%, 22.2%, 2.0%) (= 0.029, Chi-square test). Simple logistic regression analysis indicated that the Trp64Arg genotype is significantly associated with hyperuricemia (OR = 1.816, 95% CI (1.167–2.827), = 0.008). Multivariate analysis for controlling metabolic effects also showed a significant association with the occurrence of hyperuricemia (OR = 1.937, 95% CI (1.149–3.266), = 0.013). Trp64Arg polymorphism of the beta-3 adrenergic receptor may be independently associated with hyperuricemia in males.


Hyperuricemia Gout Beta-3 adrenergic receptor Polymorphism Insulin Resistance 


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Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • Young Hee Rho
    • 1
  • Seong Jae Choi
    • 1
  • Young Ho Lee
    • 1
  • Jong Dae Ji
    • 1
  • Gwan Gyu Song
    • 1
    Email author
  1. 1.Division of Rheumatology, Department of Internal MedicineKorea University Guro HospitalSeoulSouth Korea

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