Rheumatology International

, Volume 27, Issue 9, pp 869–872 | Cite as

Successful treatment of hepatitis B-associated leukocytoclastic vasculitis with lamivudine treatment in a child patient

  • Ozge Surmali Onay
  • Esra BaskinEmail author
  • Figen Ozçay
  • Engin Melek
  • Oguz Canan
  • Banu Bilezikçi
Case Report


Chronic hepatitis B infection (HBI) has many extrahepatic manifestations such as vasculitis, glomerulonephritis, arthritis, dermatitis, pulmonary disease, and skin manifestations. The mechanism of these manifestations is thought to be immune mediated. Immune-suppressive treatment may enhance viral replication and worsen hepatic disease. Lamivudine is a nucleoside analogue used in chronic HBI treatment that works by suppressing replication of the hepatitis B virus (HBV). Recently, several reports have suggested that lamivudine treats vasculitis associated with HBV infection in adults. However, there are no data in the literature for children. Herein, we report a child with leukocytoclastic vasculitis due to chronic HBI who was successfully treated with lamivudine.


Hepatitis B infection Vasculitis Treatment Lamivudine 


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Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • Ozge Surmali Onay
    • 1
  • Esra Baskin
    • 1
    • 2
    Email author
  • Figen Ozçay
    • 3
  • Engin Melek
    • 1
  • Oguz Canan
    • 1
  • Banu Bilezikçi
    • 4
  1. 1.Department of Pediatric NephrologyBaşkent University Faculty of MedicineBahçelievler, AnkaraTurkey
  2. 2.Başkent University Faculty of MedicineAnkaraTurkey
  3. 3.Department of Pediatric GastroenterologyBaşkent University Faculty of MedicineAnkaraTurkey
  4. 4.Department of PathologyBaşkent University Faculty of MedicineAnkaraTurkey

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