Abstract
Non-prescribed antacid drugs that contain magnesium and aluminum are widely used in the treatment of gastritis and peptic ulcer. One of the side effects of these antacid drugs is that they bind phosphate in the gut and result in its malabsorption. In this paper, a 42-year-old female patient who used magnesium hydroxide (Magnesie calcinee powder 100 g) to benefit from its laxative feature, and developed osteomalacia after losing 90 kg in 2 years will be presented by going through the related literature. She had widespread joint pain and could hardly walk without the help. Ca, P and vitamin D were at lower limit of normal, ALP, Mg and PTH were increased in her laboratory tests. There were stress fractures at the femur neck and at the upper part of the tibia in plane radiographies. The patient was hospitalized with the diagnosis of osteomalacia and she was treated successfully.
References
LeBoff MS, Lane N (2005) Metabolic bone disease. In: Harris ED (ed) Textbook of rheumatology, vol 2, 7th edn. WB Saunders, Philadelphia, pp 1473–1492
Harrison JE, Hitchman AJW, Hitchman et al (1980) Differences between the effects of phosphate deficiency and vitamin D deficiency on bone metabolism. Metabolism 29(12):1225–1233
Woodson GC (1998) An interesting case of osteomalacia due to antacid use associated with stainable bone aluminum in a patient with normal renal function. Bone 22(6):695–698
Neumann L, Jensen BG (1989) Osteomalacia from Al and Mg antacids. Acta Orthop Scand 60(3):361–362
Chines A, Pacifici R (1990) Antacid and sucralfate-induced hypophosphatemic osteomalacia: a case report and review of the literature. Calcif Tissue Int 47:291–295
Spencer H, Kramer L, Clemontain N et al (1982) Effects of small doses of aluminum-containing antacids on calcium and phosphorus metabolism. Am J Clin Nutr 36:32–40
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Sivas, F., Günesen, Ö., Özoran, K. et al. Osteomalacia from Mg-containing antacid: a case report of bilateral hip fracture. Rheumatol Int 27, 679–681 (2007). https://doi.org/10.1007/s00296-006-0273-6
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00296-006-0273-6