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A novel therapeutic option in Cogan diseases? TNF-α blockers

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Cogan’s syndrome is characterized by non-infectious, interstitial keratitis combined with a vestibulo-auditory deficit. Despite therapy with corticosteroids in combination with immunosuppressive agents, relapses occurred in two subjects and the clinical course suggested a progression of the disease. Treatment with anti-TNF-α was started leading to a rapid and sustained clinical remission for over 2 respectively 3 years.

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Correspondence to A. Helbling.

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Fricker, M., Baumann, A., Wermelinger, F. et al. A novel therapeutic option in Cogan diseases? TNF-α blockers. Rheumatol Int 27, 493–495 (2007).

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