Abstract
Human parvovirus B19 (B19) rarely induces pure red cell aplasia (PRCA) in healthy hosts. Meanwhile B19 infection is often clinically similar to systemic lupus erythematosus (SLE), and several cases have been reported wherein B19 actually stimulated SLE exacerbation in an immunocompetent subject. An 82-year-old healthy woman was diagnosed to have complicated with B19 infection and PRCA. Four weeks later, she had high fever, polyarthritis, and oral ulcers, additionally diagnosed with SLE, and subsequently, 15 mg of prednisone was started. This is the first case wherein B19 infection caused both PRCA and SLE in a healthy patient as far as our investigations are concerned.
References
Young NS (1995) B19 parvovirus. Baillieres Clin Haematol 8(1):25–56
Kurtzman GJ, Ozawa K, Cohen B, Hanson G, Oseas R, Young NS (1987) Chronic bone marrow failure due to persistent B19 parvovirus infection. N Engl J Med 317(5):287–294
Anderson MJ, Higgins PG, Davis LR, Willman JS, Jones SE, Kidd IM et al (1985) Experimental parvoviral infection in humans. J Infect Dis 152(2):257–265
Krantz SB (1974) Pure red-cell aplasia. N Engl J Med 291(7):345–350
Ammus SS, Yunis AA (1987) Acquired pure red cell aplasia. Am J Hematol 24(3):311–326
Diamond LK, Wang WC, Alter BP (1976) Congenital hypoplastic anemia. Adv Pediatr 22:349–378
Atzeni F, Sarzi-Puttini P, Capsoni F, Vulpio L, Carrabba M (2003) Successful treatment of pure red cell aplasia in systemic lupus erythematosus with cyclosporin A. Clin Exp Rheumatol 21(6):759–762
Mitsunaka H, Tokuda M, Takahara J, Matoba K, Miyawaki S (1998) [A case of systemic lupus erythematosus with pure red cell aplasia possibly caused by persistent infection of human parvovirus B 19]. Nihon Rinsho Meneki Gakkai Kaishi 21(5):220–225
Suzuki T, Saito S, Hirabayashi Y, Harigae H, Ishii T, Kodera T et al (2003) Human parvovirus B19 infection during the inactive stage of systemic lupus erythematosus. Intern Med 42(6):538–540
Arcasoy MO, Chao NJ (2005) T-cell-mediated pure red-cell aplasia in systemic lupus erythematosus: response to cyclosporin A and mycophenolate mofetil. Am J Hematol 78(2):161–163
Chan AY, Li EK, Tam LS, Cheng G, Choi PC (2005) Successful treatment of pure red cell aplasia associated with systemic lupus erythematosus with oral danazol and steroid. Rheumatol Int 25(5):388–390
Cossart YE, Field AM, Cant B, Widdows D (1975) Parvovirus-like particles in human sera. Lancet 1(7898):72–73
Meyer O (2003) Parvovirus B19 and autoimmune diseases. Joint Bone Spine 70(1):6–11
Meyer O, Kahn MF, Grossin M, Ribard P, Belmatoug N, Morinet F et al (1991) Parvovirus B19 infection can induce histiocytic necrotizing lymphadenitis (Kikuchi’s disease) associated with systemic lupus erythematosus. Lupus 1(1):37–41
Seve P, Ferry T, Koenig M, Cathebras P, Rousset H, Broussolle C (2005) Lupus-like presentation of parvovirus B19 infection. Semin Arthritis Rheum 34(4):642–648
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Ideguchi, H., Ohno, S. & Ishigatsubo, Y. A case of pure red cell aplasia and systemic lupus erythematosus caused by human parvovirus B19 infection. Rheumatol Int 27, 411–414 (2007). https://doi.org/10.1007/s00296-006-0227-z
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00296-006-0227-z