Skip to main content

Advertisement

SpringerLink
Log in

Antipolymer antibody is not associated with fibromyalgia in Korean female patients

  • Original Article
  • Published:
Rheumatology International Aims and scope Submit manuscript

Abstract

To examine the levels of antipolymer antibody (APA) in Korean female patients with fibromyalgia (FM) and to determine whether the levels of APA correlate with FM severity. Serum samples from patients with FM (n = 69), patients with rheumatoid arthritis (RA) (n = 71), and controls (n = 75) were assayed for APA. All of the subjects were female, and the controls were age-matched healthy volunteers. FM tender point counts and scores were examined, and FM patients were asked to complete a Korean version of the Fibromyalgia Impact Questionnaire (FIQ), the State-Trait Anxiety Inventory (STAI), and the Beck Depression Inventory (BDI). APA-positive samples were detected in five (7.2%) of the 69 FM patients, seven (9.9%) of the 71 RA patients, and four (5.3%) of the 75 controls. The prevalence of seropositivity and the level of APA in FM patients did not differ from those in RA patients and controls. The proportion positive for APA was not higher for FM patients with severe symptoms than for FM patients with mild symptoms. There was a negative association between the APA level and age. The APA level in FM patients was not correlated with age at diagnosis, age at symptom onset, disease duration, education, tender point counts and scores, FIQ, STAI, or BDI. The prevalence of APA in Korean FM patients was quite low. Owing to the low prevalence of APA in this study, the APA assay did not distinguish FM patients with severe symptoms from those with mild symptoms.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  1. Wolfe F, Smythe HA, Yunus MB, Bennett RM, Bombardier C, Goldenberg DL, Tugwell P, Campbell SM, Abeles M, Clark P et al (1990) The American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia. Report of the Multicenter Criteria Committee. Arthritis Rheum 33:160–172

    PubMed  CAS  Google Scholar 

  2. Macfarlane GJ (1999) Generalized pain, fibromyalgia and regional pain: an epidemiological view. Baillieres Best Pract Res Clin Rheumatol 13:403–414

    Article  PubMed  CAS  Google Scholar 

  3. Neumann L, Buskila D (2003) Epidemiology of fibromyalgia. Curr Pain Headache Rep 7:362–368

    PubMed  Google Scholar 

  4. Bradley LA (2005) Psychiatric comorbidity in fibromyalgia. Curr Pain Headache Rep 9:79–86

    PubMed  Google Scholar 

  5. Epstein SA, Kay G, Clauw D, Heaton R, Klein D, Krupp L, Kuck J, Leslie V, Masur D, Wagner M, Waid R, Zisook S (1999) Psychiatric disorders in patients with fibromyalgia. A multicenter investigation. Psychosomatics 40:57–63

    PubMed  CAS  Google Scholar 

  6. Henriksson C, Burckhardt C (1996) Impact of fibromyalgia on everyday life: a study of women in the USA and Sweden. Disabil Rehabil 18:241–248

    Article  PubMed  CAS  Google Scholar 

  7. Lee SS, Yoon HJ, Chang HK, Park KS (2005) Fibromyalgia in Behcet’s disease is associated with anxiety and depression, and not with disease activity. Clin Exp Rheumatol 23:S15–S19

    PubMed  CAS  Google Scholar 

  8. McBeth J, Silman AJ, Macfarlane GJ (2003) Association of widespread body pain with an increased risk of cancer and reduced cancer survival: a prospective, population-based study. Arthritis Rheum 48:1686–1692

    Article  PubMed  Google Scholar 

  9. Hochberg MC, Perlmutter DL (1996) The association of augmentation mammoplasty with connective tissue disease, including systematic sclerosis (scleroderma): a meta-analysis. Curr Top Microbiol Immunol 210:411–417

    PubMed  CAS  Google Scholar 

  10. Janowsky EC, Kupper LL, Hulka BS (2000) Meta-analyses of the relation between silicone breast implants and the risk of connective-tissue diseases. N Engl J Med 342:781–790

    Article  PubMed  CAS  Google Scholar 

  11. Perkins LL, Clark BD, Klein PJ, Cook RR (1995) A meta-analysis of breast implants and connective tissue disease. Ann Plast Surg 35:561–570

    Article  PubMed  CAS  Google Scholar 

  12. Wong O (1996) A critical assessment of the relationship between silicone breast implants and connective tissue diseases. Regul Toxicol Pharmacol 23:74–85

    Article  PubMed  CAS  Google Scholar 

  13. Borenstein D (1994) Siliconosis: a spectrum of illness. Semin Arthritis Rheum 24:1–7

    Article  PubMed  CAS  Google Scholar 

  14. Cohen SB, Rohrich RJ (1994) Evaluation of the patient with silicone gel breast implants and rheumatic complaints. Plast Reconstr Surg 94:120–125

    Article  PubMed  CAS  Google Scholar 

  15. Cuellar ML, Gluck O, Molina JF, Gutierrez S, Garcia C, Espinoza R (1995) Silicone breast implant-associated musculoskeletal manifestations. Clin Rheumatol 14:667–672

    Article  PubMed  CAS  Google Scholar 

  16. Freundlich B, Altman C, Snadorfi N, Greenberg M, Tomaszewski J (1994) A profile of symptomatic patients with silicone breast implants: a Sjogrens-like syndrome. Semin Arthritis Rheum 24:44–53

    Article  PubMed  CAS  Google Scholar 

  17. Tenenbaum SA, Rice JC, Espinoza LR, Cuellar ML, Plymale DR, Sander DM, Williamson LL, Haislip AM, Gluck OS, Tesser JR (1997) Use of antipolymer antibody assay in recipients of silicone breast implants. Lancet 349:449–454

    Article  PubMed  CAS  Google Scholar 

  18. Wilson RB, Gluck OS, Tesser JR, Rice JC, Meyer A, Bridges AJ (1999) Antipolymer antibody reactivity in a subset of patients with fibromyalgia correlates with severity. J Rheumatol 26:402–407

    PubMed  CAS  Google Scholar 

  19. Jensen B, Wittrup IH, Wiik A, Bliddal H, Friis AS, McLaughlin JK, Danneskiold-Samsoe B, Olsen JH (2004) Antipolymer antibodies in Danish fibromyalgia patients. Clin Exp Rheumatol 22:227–229

    PubMed  CAS  Google Scholar 

  20. Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, Healey LA, Kaplan SR, Liang MH, Luthra HS et al (1988) The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 31:315–324

    PubMed  CAS  Google Scholar 

  21. Kim YA, Lee SS, Park K (2002) Validation of a Korean version of the Fibromyalgia Impact Questionnaire. J Korean Med Sci 17:220–224

    PubMed  Google Scholar 

  22. Kim JT, Shin DK (1978) A study based on the standardization of the STAI for Korea. New Med J 21:69–75

    Google Scholar 

  23. Rhee MK, Lee YH, Jung HY, Choi JH, Kim SH, Kim YK, Lee SK (1995) A standardization study of Beck Depression Inventory II—Korean version (K-BDI): validity. Kor J Psychopathol 4:96–104

    Google Scholar 

  24. Rhee MK, Lee YH, Park SH, Sohn CH, Chung YC, Hong SK, Lee BK, Chang P, Yoon AR (1995) A standardization study of Beck Depression Inventory I—Korean version (K-BDI): reliability and factor analysis. Kor J Psychopathol 4:77–95

    Google Scholar 

  25. Jensen B, Wittrup IH, Wiik A, Friis S, Bliddal H, Thomsen B, McLaughlin JK, Danneskiold-Samsoe B, Olsen JH (2004) Antipolymer antibodies in Danish women with silicone breast implants. J Long Term Eff Med Implants 14:73–80

    Article  PubMed  CAS  Google Scholar 

  26. Angell M (1997) Antipolymer antibodies, silicone breast implants, and fibromyalgia. Lancet 349:1171–1172; author reply 1172–1173

    Google Scholar 

  27. Everson MP, Blackburn WD Jr (1997) Antipolymer antibodies, silicone breast implants, and fibromyalgia. Lancet 349:1171; author reply 1172–1173

    Google Scholar 

  28. Korn JH (1997) Antipolymer antibodies, silicone breast implants, and fibromyalgia. Lancet 349:1171

    Article  PubMed  CAS  Google Scholar 

  29. Tenenbaum SA, Rice JC, Espinoza LR, Garry RF (1997) Antipolymer antibodies, silicone breast implants, and fibromyalgia. Author’s reply. Lancet 349:1172–1173

    Article  Google Scholar 

  30. De Jong WH, Kallewaard M, Goldhoorn CA, Verhoef CM, Bijlsma JW, Schouten JS, Van Loveren H (2004) Long-term exposure to silicone breast implants does not induce antipolymer antibodies. Biomaterials 25:1095–1103

    Article  PubMed  CAS  Google Scholar 

  31. Dewan PA, Ashwood PJ, Rowan-Kelly B, Ferrante A, McCallum Z (2003) The detection of IgG antibodies to silicone. Pediatr Surg Int 19:20–24

    PubMed  CAS  Google Scholar 

  32. Jensen B, Wiik A, Hechmann Wittrup I, Friis S, Shen GQ, Bliddal H, McLaughlin JK, Lykke Thomsen B, Danneskiold-Samsoe B, Olsen JH (2003) Silicate antibodies in Danish women with silicone breast implants. Rheumatology (Oxford) 42:1032–1035

    Article  CAS  Google Scholar 

  33. Oliver DW, Walker MS, Walters AE, Chatrath P, Lamberty BG (2000) Anti-silicone antibodies and silicone containing breast implants. Br J Plast Surg 53:410–414

    Article  PubMed  CAS  Google Scholar 

  34. De Jong WH, Goldhoorn CA, Kallewaard M, Geertsma RE, Van Loveren H, Bijlsma JW, Schouten JS (2002) Study to determine the presence of antipolymer antibodies in a group of Dutch women with a silicone breast implant. Clin Exp Rheumatol 20:151–160

    PubMed  Google Scholar 

Download references

Acknowledgments

The authors thank Mi-Ran Kim and Young-Nan Cho for their excellent technical assistance.

Author information

Authors and Affiliations

  1. Department of Rheumatology, Chonnam National University Medical School, 5 Hak-Dong, Dong-Ku, Gwangju, 501-746, South Korea

    Shin-Seok Lee, Hyun-Jung Yoon & Yong-Wook Park

Authors
  1. Shin-Seok Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Hyun-Jung Yoon
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yong-Wook Park
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Shin-Seok Lee.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lee, SS., Yoon, HJ. & Park, YW. Antipolymer antibody is not associated with fibromyalgia in Korean female patients. Rheumatol Int 27, 73–77 (2006). https://doi.org/10.1007/s00296-006-0174-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00296-006-0174-8

Keywords

Search

Navigation