HLA-DR alleles in patients with post-streptococcal reactive arthritis
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Reactive arthritis is a term used to describe a sterile inflammatory arthritis occurring after a documented infection elsewhere in the body. Infections of the gastrointestinal, genitourinary and respiratory tract appear to provoke reactive arthritis. Acute rheumatic fever (ARF) and post-streptococcal reactive arthritis (PSReA) are the known complications of streptococcal throat infections. Not all patients infected with streptococcus causing pharyngitis result in with ARF as well as PSReA. ARF develops in 2–3% of children/adolescents infected with group A β-haemolytic streptococci causing pharyngitis. Main manifestations of ARF include carditis, migratory polyarthritis, cutaneous signs, chorea and subsequent acquired valvular disease. PSReA appeared different from that of acute rheumatic fever (ARF) and from that of HLA B27-associated reactive arthritis [1, 2, 3]. However, PSReA shares some features with ARF and with HLA B27-related spondyloarthropathies. Clinical features of the...
KeywordsPost-streptococcal reactive arthritis HLA-DR alleles
This work was supported by a research grant from Ankara University, No:2003 08 09 119.