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Rheumatology International

, Volume 27, Issue 1, pp 101–102 | Cite as

Cerebellum vasculopathy and normal tension glaucoma in systemic lupus erythematosus: report of a case and review of the literature

  • Alice Y. K. Chan
  • Edmund K. Li
  • Grace L. H. Wong
  • David T. L. LiuEmail author
Case Report

Abstract

Cerebellar vasculopathy is an uncommon but clinically important neuropsychiatric syndrome of systemic lupus erythematosus (NP-SLE) for its ominous outcome and need for prompt interventions. We described a young Chinese lady with systemic lupus erythematosus and normal tension glaucoma, who had sudden headache, nausea and vomiting coupled with rapid neurological deterioration leading to comatose status. Diagnosis of lupus cerebellar vasculopathy was made and intense immunosuppressive therapy consisting of prednisolone and cyclophosphamide was commenced. Clinical condition was salvaged with marked improvement of both sensorium and general well-being.

Keywords

Neuropsychiatric syndromes of systemic lupus erythematosus (NP-SLE) Normal tension glaucoma Cerebellum vasculopathy 

References

  1. 1.
    Grigor R, Edmonds J, Lewkonia R et al (1978) Systemic lupus erythematosus: a prospective analysis. Ann Rheum Dis 37:121–128PubMedGoogle Scholar
  2. 2.
    Johnson RT, Richardson EP (1968) The neurological manifestations of systemic lupus erythematosus: a clinicopathological study of 24 cases and review of the literature. Medicine 47:337–369PubMedGoogle Scholar
  3. 3.
    Yaginuma M, Suenaga M, Shiono Y et al (2000) Acute cerebellar ataxia of a patient with SLE. Clin Neurol Neurosurg 102:37–39PubMedCrossRefGoogle Scholar
  4. 4.
    Manto MU, Rondeaux P, Jacquy J et al (1996) Subacute pancerebellar syndrome associated with systemic lupus erythematosus. Clin Neurol Neurosurg 98:157–160PubMedCrossRefGoogle Scholar
  5. 5.
    Lancman ME, Pomeraniec C, Norscini J (1992) Magnetic resonance imaging findings in lupus ataxia. Acta Neurol Scand 86:425–426PubMedCrossRefGoogle Scholar
  6. 6.
    Smith RW, Ellison DW, Jenkins EA et al (1994) Cerebellum and brainstem vasculopathy in systemic lupus erythematosus: two clinico-pathological cases. Ann Rheum Dis 53:327–330PubMedGoogle Scholar
  7. 7.
    Singh RR, Prasad K, Kumar A et al (1988) Cerebellar ataxia in systemic lupus erythematosus: three case reports. Ann Rheum Dis 47:954–956PubMedCrossRefGoogle Scholar
  8. 8.
    Tokio S, Nobutohsi K, Tetsuo T et al (1993) Purkinje cell antibody in lupus ataxia. Lancet 342:375–346Google Scholar
  9. 9.
    Flammer J, Orgul S, Costa VP et al (2002) The impact of ocular blood flow in glaucoma. Prog Retin Eye Res 21:359–393PubMedCrossRefGoogle Scholar
  10. 10.
    Wallace DJ, Hahn BH (2002) Dubois’ lupus erythematosus. Systemic lupus erythematosus and the nervous system, 6th edn, Chapter 35, pp 693–738Google Scholar

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Alice Y. K. Chan
    • 1
  • Edmund K. Li
    • 2
  • Grace L. H. Wong
    • 2
  • David T. L. Liu
    • 3
    Email author
  1. 1.Department of HealthSocial Hygiene ServiceHong KongChina
  2. 2.Department of Medicine and Therapeutics, Prince of Wales HospitalThe Chinese University of Hong KongHong KongChina
  3. 3.Department of Ophthalmology & Visual Sciences, Prince of Wales HospitalChinese University of Hong KongHong KongChina

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