Skip to main content

Cutaneous leukocytoclastic vasculitis with cervical tuberculous lymphadenitis: a case report and literature review

Abstract

Cutaneous leukocytoclastic vasculitis (CLV) is a small-vessel vasculitis localized to the skin. Many possible causes exist for this pathological condition, including drugs, infection, collagen vascular disease, and malignancy. However, Mycobacterium tuberculosis is rarely reported to be associated with CLV. Here, we report a 49-year-old male patient that presented with fever, myalgia, and multiple palpable purpura on both of his legs. The biopsy from the purpura yielded a histologic diagnosis of leukocytoclastic vasculitis. The patient had several enlarged lymph nodes on his right neck, and the biopsy revealed tuberculous lymphadenitis. There were no signs of vasculitis present in the internal organs. After anti-tuberculosis treatment, his fever declined and the skin purpura were completely resolved. Although incidence is rare, tuberculosis should be considered as a possible cause of CLV.

This is a preview of subscription content, access via your institution.

Fig. 1
Fig. 2
Fig. 3

References

  1. Ekenstam E, Callen JP (1984) Cutaneous leukocytoclastic vasculitis. Clinical and laboratory features of 82 patients seen in private practice. Arch Dermatol 120:484–489

    Article  Google Scholar 

  2. Charles J, Ronald JF (1997) Small vessel vasculitis. N Engl J Med 20:1512–1523

    Google Scholar 

  3. Lacour JP, Castanet J, Perrin C, Vitetta A, Ortone J-P (1993) Cutaneous leukocytoclastic vasculitis and renal cancer: two cases. Am J Med 94:104–108

    PubMed  Article  CAS  Google Scholar 

  4. Sais G, Vidaller A, Jucgla A, Servitje O, Condom E, Peyri J (1998) Prognostic factors in leukocytoclastic vasculitis. Arch Dermatol 134:309–315

    PubMed  Article  CAS  Google Scholar 

  5. Bonnefoy M, Claudy AL (1988) Etude prostpective de facteurs associes aux vascularites leucocytoclasiques. Ann Dermatol Venereol 115:27–32

    PubMed  CAS  Google Scholar 

  6. Mackel SE, Jordon RE (1982) Leukocytoclastic vasculitis. A cutaneous expression of immune complex disease. Arch Dermatol 118:296–301

    PubMed  Article  CAS  Google Scholar 

  7. Sams WM Jr (1985) Human hypersensitivity angiitis, an immune complex disease. J Invest Dermatol 85:114s-148s

    Article  Google Scholar 

  8. Mertz LE, Conn DL (1992) Vasculitis associated with malignancy. Curr Opin Rheumatol 4:39–46

    PubMed  CAS  Google Scholar 

  9. Pacheco A, Mateos P, Medina J, Guisasola L, Garrillo F, Perez-Oteiza J (1987) Pulmonary tuberculosis and Schoenlein-Henoch purpura. Rev Clin Esp 180:515–517

    PubMed  CAS  Google Scholar 

  10. Chan CHS, Chong YW, Sun AJM, Hoheisel GB (1990) Cutaneous vasculitis associated with tuberculosis and its treatment. Tubercle 71:297–300

    PubMed  Article  CAS  Google Scholar 

  11. Visser AJ. Heyl T (1993) Skin tuberculosis as seen at Ga-Rankuwa hospital. Clin Exp Dermatol 18:507–515

    Article  Google Scholar 

  12. Sais G, Vidaller A, Jucgla A, Peyri J (1996) Tuberculous lymphadenitis presenting with cutaneous leukocytoclastic vasculitis. Clin Exp Dermatol 21:65–66

    PubMed  Article  CAS  Google Scholar 

  13. Lee AY, Jang JH, Lee KH (1998) Two cases of leukocytoclastic vasculitis with tuberculosis. Clin Exp Dermatol 23:225–226

    PubMed  Article  CAS  Google Scholar 

  14. Martinez V, Zeller V, Caumes E, Katlama C, Bricaire F (2000) Cutaneous vascultitis disclosing pulmonary tuberculosis. Ann Med Intern 151:664–666

    CAS  Google Scholar 

  15. Minguez P, Pintor E, Buron R, Diaz-Pollan B, Puche JJ, Pontes JC (2000) Pulmonary tuberculosis presenting with cutaneous leukocytoclastic vasculitis. Infection 28:55–57

    PubMed  Article  CAS  Google Scholar 

  16. Johnson NMcl, McNicol MW, Burton Kee EJ, Mowbray JF (1981) Circulating immune complexes in tuberculosis. Thorax 36:610–617

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Soo-Kon Lee.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Kim, H.M., Park, YB., Maeng, H.Y. et al. Cutaneous leukocytoclastic vasculitis with cervical tuberculous lymphadenitis: a case report and literature review . Rheumatol Int 26, 1154–1157 (2006). https://doi.org/10.1007/s00296-006-0152-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00296-006-0152-1

Keywords

  • Leukocytoclastic vasculitis
  • Mycobacterium tuberculosis