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Rheumatology International

, Volume 25, Issue 3, pp 161–168 | Cite as

Macroscopic and radiological grading of osteoarthritis correlates inadequately with cartilage height and histologically demonstrable damage to cartilage structure

  • Andre SaalEmail author
  • J. Gaertner
  • M. Kuehling
  • Bernd Swoboda
  • Stefan Klug
Review Article

Abstract

Introduction: The aim of the present study was to investigate different methods for determining osteoarthritis-related (OA) cartilaginous changes. Materials and methods: Human tibial heads were investigated radiologically, macroscopically and microscopically. The height of the hyaline cartilage was measured with the aid of a computerised digital image analysis system. Results: The comparison of the different evaluation systems revealed, in part, appreciable variations in severity and produced correlations of r=−0.312–0.673. In none of the methods was a linear correlation between the histomorphometrically measured decrease in cartilage height and the increasing grade of OA evident. Discussion: The microscopic scores are superior, since they provide the most precise description of cartilaginous structure. The variation in cartilage height with increasing OA is not a linear process; measurement of the cartilage height alone is not a valid parameter for determining the grade of OA.

Keywords

Articular Cartilage Standard Deviation Tibial Plateau Hyaline Cartilage Cartilage Thickness 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • Andre Saal
    • 1
    Email author
  • J. Gaertner
    • 2
  • M. Kuehling
    • 3
  • Bernd Swoboda
    • 4
  • Stefan Klug
    • 5
  1. 1.Bad NeustadtGermany
  2. 2.NuernbergGermany
  3. 3.HerzogenaurachGermany
  4. 4.Waldkrankenhaus St. Marien, Division of Orthopaedic RheumatologyErlangenGermany
  5. 5.ErlangenGermany

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