Abstract
Familial Mediterranean fever (FMF) is a multisystem disease characterized by recurrent polyserositis episodes seen in certain ethnic groups. In recent years the clinical picture of FMF has been expanded and severe myalgia is a frequently recognized component of the syndrome. Protracted febrile myalgia syndrome (PFMS), characterized by severe paralyzing myalgia, high fever, abdominal pain, diarrhea, arthritis/arthralgia, and transient vasculitic rashes mimicking Henoch-Schonlein purpura, was first described in patients with FMF in 1994. We describe an 11-year-old Turkish girl with a second attack of PFMS before being diagnosed as having FMF, emphasizing the importance of myalgia for the diagnosis of FMF even in the absence of other symptoms.
Similar content being viewed by others
References
Langevitz P, Zemer D, Livneh A, Shemer J, Pras M (1994). Protracted myalgia syndrome in patients with familial Mediterranean fever. J Rheumatol 21:1708–1709
Majeed HA, Al-Qudah AK, Qubain H, Shahin HM (2000). The clinical patterns of myalgia in children with familial Mediterranean fever. Sem Arthritis Rheum 30:138–143; 92:309–318
Majeed HA, Rawashdeh M, El-Shanti H, Qubain H, Khuri-Bulos N, Shahin HM (1999) Familial Mediterranean fever in children: the expanded clinical profile. Q J Med 92:309–318
Livneh A, Langevitz P, Zemer D, Kees S, Lidar T (1997) Criteria for the diagnosis of familial Mediterranean fever. Arthritis Rheum 40:1879–1885
Livneh A ( 2000) The role of diagnostic criteria in familial Mediterranean fever. Familial Mediterranean fever II. International Conference, Antalya, Turkey. Lect Abst, pp 37–41
Ramanan AV, Feldman BM (2002) Clinical outcomes in juvenile dermatomyositis Curr Opin Rheumatol 14:658–662
Sundel R, Szer I (2002). Vasculitis in childhood. Rheum Dis Clin N Am 28:625–654
Heller H, Sohar E, Sherf L (1958) Familial Mediterranean fever. Arch Int Med 102:50–56
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Soylu, A., Őztürk, Y., Kasap, B. et al. Clinical quiz: A pediatric case presenting with fever and diffuse myalgia. Rheumatol Int 25, 314–316 (2005). https://doi.org/10.1007/s00296-004-0530-5
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00296-004-0530-5