Rheumatology International

, Volume 25, Issue 3, pp 234–237 | Cite as

Successful treatment with stent angioplasty for Budd-Chiari syndrome in Behçet’s disease

  • Seung Woo Han
  • Gun Woo Kim
  • Jongmin Lee
  • Yong Joo Kim
  • Young Mo KangEmail author
Case Report


Budd-Chiari syndrome (BCS) is a very rare vascular complication of Behçet’s disease (BD) which often leads to death as a result of portal hypertension and liver failure. We report a 45-year-old BD patient who presented with BCS. Diagnosis was confirmed with CT scan and contrast-enhanced MR angiography which showed ascites, short-segment stenosis of the inferior vena cava (IVC), and middle and left hepatic venous thrombosis. Percutaneous transluminal angioplasty (PTA) of the obstructed segment in the IVC was performed and resulted in dramatic reduction of portal venous pressure. Our experience indicates that PTA may be a safe and effective therapeutic modality for BCS in BD which is caused by short segmental obstruction of the IVC.


Behçet’s disease Budd-Chiari syndrome Percutaneous transluminal angioplasty 


  1. 1.
    Kiraz S, Ertenli I, Ozturk MA, Haznedaroglu IC, Celik I, Calguneri M (2002) Pathological haemostasis and “prothrombotic state” in Behçet’s disease. Thromb Res 105:125–133CrossRefPubMedGoogle Scholar
  2. 2.
    Bayraktar Y, Balkanci F, Bayraktar M, Calguneri M (1997) Budd-Chiari syndrome: a common complication of Behçet’s disease. Am J Gastroenterol 92:858–862PubMedGoogle Scholar
  3. 3.
    Shimizu T, Ehrlich GE, Inaba G, Hayashi K (1979) Behçet disease (Behçet syndrome). Semin Arthritis Rheum 8:223–260CrossRefPubMedGoogle Scholar
  4. 4.
    Ringe B, Lang H, Oldhafer KJ, Gebel M, Flemming P, Georgii A, Borst HG, Pichlmayr R (1995) Which is the best surgery for Budd-Chiari syndrome: venous decompression or liver transplantation? A single-center experience with 50 patients. Hepatology 21:1337–1344CrossRefPubMedGoogle Scholar
  5. 5.
    Slakey DP, Klein AS, Venbrux AC, Cameron JL (2001) Budd-Chiari syndrome: current management options. Ann Surg 233:522–527CrossRefPubMedGoogle Scholar
  6. 6.
    Pelage JP, Denys A, Valla D, Sibert A, Sauvanet A, Belghiti J, Menu Y (2003) Budd-Chiari syndrome due to prothrombotic disorder: mid-term patency and efficacy of endovascular stents. Eur Radiol 13:286–293PubMedGoogle Scholar
  7. 7.
    Cakaloglu Y, Okten A, Yalcin S (1991) Serum-ascites albumin concentration gradient (A-GRAD) in the prediction of portal hypertension in ascitic patients. Gastroenterology 100:1484–1485PubMedGoogle Scholar
  8. 8.
    Fisher NC, McCafferty I, Dolapci M, Wali M, Buckels JA, Olliff SP, Elias E (1999) Managing Budd-Chiari syndrome: a retrospective review of percutaneous hepatic vein angioplasty and surgical shunting. Gut 44:568–574PubMedGoogle Scholar
  9. 9.
    Hendrick RE (1987) Sampling time effects on signal-to-noise and contrast-to-noise ratios in spin-echo MRI. Magn Reson Imaging 5:31–37CrossRefPubMedGoogle Scholar
  10. 10.
    Wu T, Wang L, Xiao Q, Wang B, Li S, Li X, Zhang J (2002) Percutaneous balloon angioplasty of inferior vena cava in Budd-Chiari syndrome-R1. Int J Cardiol 83:175–178CrossRefPubMedGoogle Scholar
  11. 11.
    Townsend (2001) Anatomy and development of liver. In: Sabiston textbook of surgery. Saunders, Phladelphia, pp 1002–1003Google Scholar
  12. 12.
    O’Duffy JD (1990) Vasculitis in Behçet’s disease. Rheum Dis Clin North Am 16:423–431PubMedGoogle Scholar
  13. 13.
    Ozoran K, Dugun N, Gurler A, Tutkak H, Tokgoz G (1995) Plasma von Willebrand factor, tissue plasminogen activator, plasminogen activator inhibitor, and antithrombin III levels in Behçet’s disease. Scand J Rheumatol 24:376–382PubMedGoogle Scholar
  14. 14.
    Haznedaroglu IC, Ozdemir O, Ozcebe O, Dundar SV, Kirazli S (1996) Circulating thrombomodulin as a clue of endothelial damage in Behçet’s disease. Thromb Haemost 75:974–975PubMedGoogle Scholar
  15. 15.
    Aydintug AO, Tokgoz G, D’Cruz DP, Gurler A, Cervera R, Duzgun N, Atmaca LS, Khamashta MA, Hughes GR (1993) Antibodies to endothelial cells in patients with Behçet’s disease. Clin Immunol Immunopathol 67:157–162CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  • Seung Woo Han
    • 1
  • Gun Woo Kim
    • 1
  • Jongmin Lee
    • 2
  • Yong Joo Kim
    • 2
  • Young Mo Kang
    • 1
    Email author
  1. 1.Division of Rheumatology, Department of Internal MedicineKyungpook National University School of MedicineJunggu700–721 Republic of Korea
  2. 2.Department of Diagnostic RadiologyKyungpook National University School of MedicineJungguRepublic of Korea

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