Rheumatology International

, Volume 25, Issue 7, pp 518–521 | Cite as

The prevalence of diffuse idiopathic skeletal hyperostosis in patients with diabetes mellitus

  • D. Sencan
  • H. Elden
  • V. Nacitarhan
  • M. Sencan
  • E. Kaptanoglu

Abstract

Objective

The relation of diffuse idiopathic skeletal hyperostosis (DISH) and diabetes mellitus (DM) has been frequently reported. However, there is little knowledge about its prevalence in DM. The purpose of this study was to determine that prevalence and whether it differs from that of controls.

Methods

The prevalence of DISH was investigated in 133 patients with DM and 133 nondiabetic controls matched for sex, age, and weight. Radiologic criteria were used for diagnosis. Erythrocyte sedimentation rate, fasting blood glucose levels, glycolized hemoglobin, triglyceride, very low-density lipoprotein, low-density lipoprotein, high-density lipoprotein, calcium, uric acid, alkaline phosphatase, phosphorus, insulin, and insulin-like growth factor-1 (IGF1) levels of both groups were compared.

Results

The prevalence of DISH (12%) was higher in patients with DM than the control group (6.8%), but there was no statistically significant difference. The average age of the patients diagnosed with DISH (63.36±9.27) was significantly higher than that of the others (54.21±12.12) (P<0.05). There was no significant difference between the DISH patients and the others in other parameters examined.

Conclusion

We found no statistically significant difference in the prevalence of DISH between patients with DM and controls. We suggest that the factors thought to be responsible for the etiopathogenesis of DISH such as DM, insulin, and insulin-like growth factor-1 be investigated further.

Keywords

Diabetes mellitus Diffuse idiopathic skeletal hyperostosis Insulin-like growth factor 

References

  1. 1.
    Utsinger PD (1985) Diffuse idiopathic skeletal hyperostosis. Clin Rheum Dis 11:325–350PubMedGoogle Scholar
  2. 2.
    Moskowitzt WR (1997) Clinical and laboratory findings in osteoarthritis. In: Koopman WJ (ed) Arthritis and allied conditions. A textbook of rheumatology, 13th edn. Williams and Wilkins, Baltimore, pp 1985–2011Google Scholar
  3. 3.
    Mata S, Fortin PR, Fritcharles MA et al (1997) A controlled study of diffuse idiopathic skeletal hyperostosis. Medicine 76:104–117CrossRefPubMedGoogle Scholar
  4. 4.
    Doyle TCA, Littlejohn G (1986) The radiological features of diffuse idiopathic skeletal hyperostosis (D.I.S.H.). Australas Radiol 30:76–80PubMedGoogle Scholar
  5. 5.
    Schlapbach P, Beyeler CH, Gerber NJ et al (1992) The prevalence of palpable finger joint nodules in diffuse idiopathic skeletal hyperostosis (DISH). A controlled study. Br J Rheumatol:31:531–534Google Scholar
  6. 6.
    Beyeler JH, Schlapbach P, Gerber NJ et al (1992) Diffuse idiopathic skeletal hyperostosis of the elbow: a cause of elbow pain? A controlled study. Br J Rheumatol:31:319–323Google Scholar
  7. 7.
    Rotes-Querol J (1996) Clinical manifestations of diffuse idiopathic skeletal hyperostosis (DISH). Br J Rheumatol:35:1193–1194Google Scholar
  8. 8.
    Littlejohn GO, Urowitz MB (1982) Peripheral enthesopathy in diffuse idiopathic skeletal hyperostosis (DISH). A radiological study. J Rheumatol:9:568–572Google Scholar
  9. 9.
    Huang GS, Park YH, Taylor JAM et al (1993) Hyperostosis of ribs: association with vertebral ossification. J Rheumatol 20:2073–2076PubMedGoogle Scholar
  10. 10.
    Robbes-Ruy E, Rojo-Mejia A, Calderon HG et al (1982) Diffuse idiopathic skeletal hyperostosis: clinical and radiological manifestations in 50 patients. Arthritis Rheum 25:101–106PubMedGoogle Scholar
  11. 11.
    Daragon A, Mejjad O, Czernichow P et al (1995) Vertebral hyperostosis and diabetes mellitus: a case control study. Ann Rheum Dis:54:375–378Google Scholar
  12. 12.
    Symthe H, Littlejohn G (1994) Diffuse idiopathic skeletal hyperostosis. In: Klippel JH, Dieppe PA (eds) Rheumatology. Mosby, Hong Kong, 7:9, pp 1–6Google Scholar
  13. 13.
    Julkunen H, Karava R, Viljanen V (1966) Hyperostosis of the spine in diabetes mellitus and acromegaly. Diabetologia 2:123–126PubMedGoogle Scholar
  14. 14.
    Haykova Z, Streda A, Skrha F (1965) Hyperostotic spondylosis and diabetes mellitus. Ann Rheum Dis 24:536–543PubMedGoogle Scholar
  15. 15.
    Knopp RG, Miller MC III (1991) Clinical epidemiology and biostatistics. Williams and Wilkins, BaltimoreGoogle Scholar
  16. 16.
    Sümbüloğlu K, Sümbüloğlu V (1990) Biostatistik. Baskı, AnkaraGoogle Scholar
  17. 17.
    American Diabetes Association (2000). Screening for diabetes. Diabetes Care 23:80–82PubMedGoogle Scholar
  18. 18.
    Resnick D, Niwayama G (1976) Radiographic and pathologic features of spinal involvement in diffuse idiopathic skeletal hyperostosis (DISH). Radiology 119:559–568PubMedGoogle Scholar
  19. 19.
    Littlejohn GO, Symthe HA (1981) Marked hyperinsulinemia after glucose challenge in patients with diffuse idiopathic skeletal hyperostosis. J Rheumatol 8:965–968PubMedGoogle Scholar
  20. 20.
    Moskowitch RW, Boja B, Denko JW (1991) The role of growth factor in degenerative joint disorders. J Rheumatol 18:147–148PubMedGoogle Scholar
  21. 21.
    El Garf A, Khater R (1984) Diffuse idiopathic skeletal hyperostosis (DISH). A clinicoradiological study of the disease pattern in Middle Eastern populations. J Rheumatol 11:804–807PubMedGoogle Scholar
  22. 22.
    Cassim B, Mody GM, Rubin DL (1990) The prevalence of diffuse idiopathic skeletal hyperostosis in African blacks. Br J Rheumatol 29:131–132PubMedGoogle Scholar
  23. 23.
    Vezyroglou G, Mitropoulos A, Kyriazis N et al (1996) A metabolic syndrome in diffuse idiopathic skeletal hyperostosis. A controlled study. J Rheumatol 23:672–676PubMedGoogle Scholar
  24. 24.
    Bloom RA (1984) The prevalence of ankylosing hyperostosis in a Jerusalem population—with description of a method of grading the extent of the disease. Scand J Rheumatol 13:181–189PubMedGoogle Scholar
  25. 25.
    Denko CW, Boja B, Moskowitch RW (1994) Growth promoting peptides in osteoarthritis and diffuse idiopathic skeletal hyperostosis-insulin, insulin-like growth factor-1, and growth hormone. J Rheumatol 21:1725–1730PubMedGoogle Scholar
  26. 26.
    Denko CW, Boja B, Malemud CJ (2002) Growth hormone and insulin-like growth factor-1 in symptomatic and asymptomatic patients with diffuse idiopathic skeletal hyperostosis (DISH). Front Biosci 7:37–43Google Scholar

Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  • D. Sencan
    • 1
  • H. Elden
    • 1
  • V. Nacitarhan
    • 1
  • M. Sencan
    • 2
  • E. Kaptanoglu
    • 1
  1. 1.Department of Physical Medicine and RehabilitationMedicine Faculty, Cumhuriyet UniversitySivasTurkey
  2. 2.Department of HematologyMedicine Faculty, Cumhuriyet UniversitySivasTurkey

Personalised recommendations