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The effect of interleukin-1 blockade on fatigue in rheumatoid arthritis—a pilot study

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Abstract

Fatigue occurs in many patients with rheumatoid arthritis (RA) and other chronic inflammatory diseases and may be defined as an overwhelming sense of tiredness, lack of energy, and feeling of exhaustion. It can be restrictive and severely disabling. We recently found more than 3/4 of systemic lupus erythematosus patients to be significantly affected by this phenomenon. We hypothesized that fatigue in patients with RA might be comparable to sickness behavior in animals possibly caused by disturbances in interleukin-1 beta signaling pathways and thus accessible to blockade by biologic agents. This study compared measures of disease behavior and fatigue symptoms in eight RA patients before and at three time points during treatment with daily administration of anakinra.

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References

  1. Wolfe F, Hawley DJ, Wilson K (1996) The prevalence and meaning of fatigue in rheumatic diseases. J Rheumatol 23:1407–1417

    CAS  PubMed  Google Scholar 

  2. Koike T, Kazuma K, Kawamura S (2000) The relationship between fatigue, coping behavior, and inflammation in patients with rheumatoid arthritis. Mod Rheumatol 10:141–149

    Article  Google Scholar 

  3. Krupp LB, LaRocca NG, Muir J, Steinberg AD (1990) A study of fatigue in systemic lupus erythematosus. J Rheumatol 17:1450–1452

    CAS  PubMed  Google Scholar 

  4. Tench CM, McCurdie I, White PD, D’Cruz DP (2000) The prevalence of fatigue in systemic lupus erythematosus. Rheumatology 39:1249–1254

    Article  CAS  PubMed  Google Scholar 

  5. Omdal R, Mellgren SI, Koldingsnes W, Jacobsen EA, Husby G (2002) Fatigue in patients with systemic lupus erythematosus: lack of associations to serum cytokines, antiphospholipid antibodies, or other disease characteristics. J Rheumatol 29:482–486

    PubMed  Google Scholar 

  6. Comi G, Leocani L, Rossi P, Colombo B (2001) Physiopathology and treatment of fatigue in multiple sclerosis. J Neurol 248:174–179

    Article  CAS  PubMed  Google Scholar 

  7. Kurzrock R (2001) The role of cytokines in cancer-related fatigue. Cancer [Suppl] 92:1684–1688

    Google Scholar 

  8. Krupp LB, Pollina DA (1996) Mechanisms and management of fatigue in progressive neurological disorders. Curr Opin Neurol 9:456–460

    CAS  PubMed  Google Scholar 

  9. Kelley KW, Hutchison K, French R et al (1997) Central interleukin-1 receptors as mediators of sickness. In: Moore PM, Lahita RG (eds) Neuropsychiatric manifestations of systemic lupus erythematosus. Ann N Y Acad Sci 823:234–246

    CAS  PubMed  Google Scholar 

  10. Rinehart J, Hersh E, Issell B, Triozzi P, Buhles W, Neidhart J (1997) Phase 1 trial of recombinant human interleukin-1 beta (rhIL-1 beta), carboplatin, and etoposide in patients with solid cancers: Southwest Oncology Group Study 8940. Cancer Invest 15:403–410

    CAS  PubMed  Google Scholar 

  11. Farrar WL, Killian PL, Ruff MR, Hill JM, Pert CB (1987) Visualization and characterization of interleukin-1 receptors in brain. Endocrinology 139:459–463

    CAS  Google Scholar 

  12. Konsman JP, Blond D, Vigues S (2000) Neurobiology of interleukin-1 receptors: getting the message. Eur Cytokine Netw 11:699–702

    CAS  PubMed  Google Scholar 

  13. Carrié A, Jun L, Bienvenu T et al (1999) A new member of the IL-1 receptor family highly expressed in hippocampus and involved in X-linked mental retardation. Nature Genetics 23:25–31

    PubMed  Google Scholar 

  14. Arnett FC, Edworthy SM, Bloch DA et al (1988) The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 31:315–324

    CAS  PubMed  Google Scholar 

  15. http://www.das-score.nl/www.das-score.nl/DAS-frame-1.htm

  16. Krupp LB, LaRocca NG, Muir-Nash J, Steinberg AD (1989) The fatigue severity scale. Application to patients with multiple sclerosis and systemic lupus erythematosus. Arch Neurol 46:1121–1123

    CAS  PubMed  Google Scholar 

  17. Bresnihan B (2001) The prospect of treating rheumatoid arthritis with recombinant human interleukin-1 receptor antagonist. Bio Drugs 15:87–97

    CAS  Google Scholar 

  18. Guyatt GH, Townsend M, Berman LB, Keller JL (1987) A comparison of Likert and visual analogue scales for measuring change in function. J Chron Dis 40:1129–1133

    CAS  PubMed  Google Scholar 

  19. Wang B, Gladman DD, Urowitz MB (1998) Fatigue in lupus is not correlated with disease activity. J Rheumatol 25:892–895

    CAS  PubMed  Google Scholar 

  20. Bruce IN, Mak VC, Hallett DC, Gladman DD, Urowitz MB (1999) Factors associated with fatigue in patients with systemic lupus erythematosus. Ann Rheum 58:379–381

    CAS  Google Scholar 

  21. Omdal R, Waterloo K, Koldingsnes W, Husby G, Mellgren SI (2003) Fatigue in patients with systemic lupus erythematosus: the psychosocial aspects. J Rheumatol 30:283–287

    PubMed  Google Scholar 

  22. Schiller JH, Storer BE, Witt PL et al (1991) Biological and clinical effects of intravenous tumor necrosis factor-α administered three times weekly. Cancer Res 51:1651–1658

    CAS  PubMed  Google Scholar 

  23. Layé S, Lundkvist J, Bartfai T (1999) Cytokines in the brain. In: Thèze J (ed) The cytokine network and immune functions. Oxford University Press, New York, pp 262–269

  24. Greenberg DB, Gray JL, Mannix CM, Eisenthal S, Carey M (1993) Treatment-related fatigue and serum interleukin-1 levels in patients during external beam irradiation for prostate cancer. J Pain Symptom Manage 8:196–200

    CAS  PubMed  Google Scholar 

  25. Riemsa RP, Rasker JJ, Taal E, Griep EN, Wouters JMGW, Wiegman O (1998) Fatigue in rheumatoid arthritis: the role of self-efficacy and problematic social support. Br J Rheumatol 37:1042–1046

    Article  PubMed  Google Scholar 

  26. Belza BL (1995) Comparison of self-reported fatigue in rheumatoid arthritis and controls. J Rheumatol 22:639–643

    CAS  PubMed  Google Scholar 

  27. Giovannoni G, Thompson AJ, Miller DH, Thompson EJ (2001) Fatigue is not associated with raised inflammatory markers in multiple sclerosis. Neurology 57:676–681

    CAS  PubMed  Google Scholar 

  28. Bakshi R, Miletich RS, Henschel K et al (1999) Fatigue in multiple sclerosis: cross-sectional correlation with brain MRI findings in 71 patients. Neurology 53:1151–1153

    CAS  PubMed  Google Scholar 

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Acknowledgement

The authors would like to thank Mrs. Monica Crossman Meling for linguistic help.

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Correspondence to Roald Omdal.

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Omdal, R., Gunnarsson, R. The effect of interleukin-1 blockade on fatigue in rheumatoid arthritis—a pilot study. Rheumatol Int 25, 481–484 (2005). https://doi.org/10.1007/s00296-004-0463-z

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  • DOI: https://doi.org/10.1007/s00296-004-0463-z

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