Rheumatology International

, Volume 25, Issue 3, pp 183–187 | Cite as

Reactivation of Epstein-Barr virus in patients with systemic lupus erythematosus

  • Mary L. HugginsEmail author
  • Ian Todd
  • Richard J. Powell
Original Article


A link between Epstein-Barr Virus (EBV) and systemic lupus erythematosus (SLE) has been suggested. However, recent advances in molecular technology now permit more detailed analysis. Sera from SLE patients were tested for antibodies to several EBV antigens and had a significantly higher prevalence of immunoglobulin G antibodies against EBV early antigens than in normal or disease controls. This suggests that recent EBV infection or virus reactivation was occurring in these patients.


Antibodies Epstein-Barr virus Reactivation Systemic lupus erythematosus 



We are grateful to the Jones Charitable Trust for funding.


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Copyright information

© Springer-Verlag 2003

Authors and Affiliations

  • Mary L. Huggins
    • 1
    Email author
  • Ian Todd
    • 1
  • Richard J. Powell
    • 1
  1. 1.Division of Immunology, School of Molecular Medical SciencesUniversity of Nottingham, Queen’s Medical CentreNottingham NG7 2UHU.K.

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