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Rheumatology International

, Volume 25, Issue 3, pp 179–182 | Cite as

Interleukin-1β gene polymorphisms in Taiwanese patients with gout

  • Man-Ling Chen
  • Chung-Ming Huang
  • Chang-Hai Tsai
  • Fuu-Jen TsaiEmail author
Original Article

Abstract

The purpose of this study was to examine whether interleukin-1 beta (IL-1β) promoter and exon 5 gene polymorphisms are markers of susceptibility or clinical manifestations in Taiwanese patients with gout. The study included 196 patients in addition to 103 unrelated healthy control subjects living in central Taiwan. From genomic DNA, polymorphisms of the gene for IL-1β promoter and IL-1β exon 5 were typed. Allelic frequencies were compared between the two groups, and the relationship between allelic frequencies and clinical manifestations of gout was evaluated. No significant differences were observed in the allelic frequencies of the IL-1β promoter between patients with gout and healthy control subjects. Additionally, we did not detect any association of the IL-1β promoter genotype with the clinical and laboratory profiles of gout patients. However, there was a significant difference between the two groups in terms of hypertriglyceridemia (P=0.0004, χ2=12.52, OR 7.14, 95%CI 0.012–0.22). There was also a significant difference in the genotype of IL-1β exon 5 polymorphism between patients with and without hypertriglyceridemia. Results of the present study suggest that polymorphisms of the IL-1β promoter and IL-1β exon 5 are not related to gout patients in central Taiwan.

Keywords

Interleukin-1 beta Gene polymorphism Gout 

Notes

Acknowledgement

This study was supported by a grant (DMR-90-107) from the China Medical University Hospital of Taiwan.

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Copyright information

© Springer-Verlag 2003

Authors and Affiliations

  • Man-Ling Chen
    • 1
  • Chung-Ming Huang
    • 1
  • Chang-Hai Tsai
    • 2
  • Fuu-Jen Tsai
    • 1
    Email author
  1. 1.Department of Medical Genetics, China Medical University HospitalCollege of Chinese Medicine, China Medical UniversityTaichungTaiwan
  2. 2.Graduate Institute of BioinformaticsTaichung Healthcare and Management UniversityTaichungTaiwan

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