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Paraneoplastic eosinophilic fasciitis: a case report

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Abstract

A 60-year-old white woman with polycythemia rubra vera post splenectomy in November 2001 was found to have peripheral white blood cell counts increasing over 3 months. Cytogenetics revealed trisomy of chromosomes 8 and 9, and bone marrow biopsy showed hypercellular, fibrotic bone marrow consistent with myelofibrosis of polycythemia rubra vera. Two months later, the patient developed acute swelling and pain in her lower extremities. The clinical symptoms along with confirmatory histology supported the diagnosis of eosinophilic fasciitis. This is the first reported case in the English literature of an association between polycythemia vera and eosinophilic fasciitis.

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Fig. 1A–C.

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Acknowledgement

We would like to thank Vladimir Vincek, MD, for taking the histologic photographs.

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Authors and Affiliations

  1. Department of Dermatology and Cutaneous Surgery, University of Miami School of Medicine, Miami, Fla., USA

    Sharon E. Jacob, Rashmi Lodha, Paolo Romanelli & Robert S. Kirsner

  2. Department of Epidemiology and Public Health, University of Miami School of Medicine, Miami, Fla., USA

    Robert S. Kirsner

  3. Department of Hematology, University of Miami School of Medicine, Miami, Fla., USA

    Jonathan J. Cohen

  4. Department of Dermatology, Veterans Administration Medical Center, 1201 NW 16th St., Miami, FL 33125, USA

    Robert S. Kirsner

Authors
  1. Sharon E. Jacob
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  2. Rashmi Lodha
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  3. Jonathan J. Cohen
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  4. Paolo Romanelli
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  5. Robert S. Kirsner
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Corresponding author

Correspondence to Robert S. Kirsner.

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Jacob, S.E., Lodha, R., Cohen, J.J. et al. Paraneoplastic eosinophilic fasciitis: a case report. Rheumatol Int 23, 262–264 (2003). https://doi.org/10.1007/s00296-003-0317-0

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  • DOI: https://doi.org/10.1007/s00296-003-0317-0

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