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Using 99mTc HMPAO brain SPECT to evaluate the effects of anticoagulant therapy on regional cerebral blood flow in primary antiphospholipid antibody syndrome patients with brain involvement—a preliminary report

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Abstract

Technetium-99m hexamethylpropylene amine oxime (99mTc HMPAO) brain single photon emission computed tomography (SPECT) was used to evaluate the effects of anticoagulant therapy (ACT) on regional cerebral blood flow (rCBF) in patients with primary antiphospholipid antibody syndrome (PAPS). Sixteen female PAPS patients with neuropsychiatric manifestations and hypoperfusion lesions demonstrated on initial 99mTc HMPAO brain SPECT images were enrolled in this study. Follow-up 99mTc HMPAO brain SPECT images were performed 1 month after ACT. Meanwhile, serum anticardiolipin antibodies (ACA) were measured before and after ACT. Before ACT, 14 (87.5%) patients had positive ACA. After ACT, all 16 PAPS patients showed decreased serologic findings, and their neuropsychiatric manifestations subsided . After ACT, 11 (68.8%) patients showed complete recovery of regional cerebral blood flow (rCBF) and five (31.2%) patients showed partial recovery in the follow-up 99mTc HMPAO brain SPECT images. This type of imaging is a logical and objective tool for measuring the effects of ACT in PAPS patients with brain involvement by determining changes in rCBF.

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Authors and Affiliations

  1. Department of Nuclear Medicine, China Medicine College Hospital, Taichung, Taiwan

    S. S. Sun & C. H. Kao

  2. Department of Nuclear Medicine, Far Eastern Memorial Hospital, Taipei, Taiwan

    F. Y. Liu

  3. Graduate Institute of Bioinformatics, Taichung Healthcare and Management University, Taichung, Taiwan

    J. J. P. Tsai

  4. Department of Nuclear Medicine, National Taiwan University Hospital, Taipei, Taiwan

    R. F. Yen

  5. Department of Nuclear Medicine, National Defense Medical Center, Tri-Service General Hospital, No. 325, Sec. 2, Cherng-Kung Rd., Neihu 114, Taipei, Taiwan

    W. S. Huang

Authors
  1. S. S. Sun
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  2. F. Y. Liu
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  3. J. J. P. Tsai
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  4. R. F. Yen
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  5. C. H. Kao
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  6. W. S. Huang
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Correspondence to W. S. Huang.

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Sun, S.S., Liu, F.Y., Tsai, J.J.P. et al. Using 99mTc HMPAO brain SPECT to evaluate the effects of anticoagulant therapy on regional cerebral blood flow in primary antiphospholipid antibody syndrome patients with brain involvement—a preliminary report. Rheumatol Int 23, 301–304 (2003). https://doi.org/10.1007/s00296-003-0314-3

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  • DOI: https://doi.org/10.1007/s00296-003-0314-3

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