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Peripheral T cell lymphoma-associated hemophagocytic syndrome in a patient with human adjuvant disease

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Abstract

Hemophagocytic syndrome (HPS) is a rare complication of lymphoma. We report a 70-year-old woman with human adjuvant disease who developed lymphoma-associated HPS (LAHPS) and elevated serum soluble interleukin (IL)-2 receptor. Despite intensive therapy, she died of pneumonia. Necropsy revealed a prominent spleen containing atypical T cells and many erythrophagocytizing histiocytes.

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References

  1. Risdall RJ, McKenna RW, Nesbit ME (1979) Virus-associated hemophagocytic syndrome. A benign histiocytic proliferation distinct from malignant histiocytosis. Cancer 44: 993–1002

    CAS  PubMed  Google Scholar 

  2. Wong KF, Hui PK, Chan JLC (1991) The acute lupus hemophagocytic syndrome. Ann Int Med 114: 387–390

    CAS  Google Scholar 

  3. Negishi M, Kasama T, Iwabuchi H, Kanemitsu H, Ide H (2002) Autoimmune-associated hemophagocytic syndrome in a patient with rheumatoid arthritis. Clin Rheumatol 21: 87–88

    CAS  PubMed  Google Scholar 

  4. Miyoshi K, Miyaoka T, Kobayashi Y (1964) Hypergammaglobulinemia by prolonged adjuvanticity in man: disorders developed after augmentation mammoplasty. Ijishimpo 2122: 9–14

    Google Scholar 

  5. Wilson MS, Weiss LM, Gatter KC, Mason DY, Dorfman RF, Warnke RA (1990) Malignant histiocytosis. A reassessment of cases previously reported in 1975 based on paraffin section immunophenotyping studies. Cancer 66: 530–536

    CAS  PubMed  Google Scholar 

  6. Falini B, Pileri S, De Solas I, Martelli MF, Mason DY, Delsol G, Gatter KC, Fagioli M (1990) Peripheral T-cell lymphoma associated with hemophagocytic syndrome. Blood 75: 434–444

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Division of Rheumatology and Clinical Immunology, First Department of Internal Medicine, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, Japan

    Masao Negishi, Tsuyoshi Kasama, Ryosuke Hanaoka & Hirotsugu Ide

  2. Department of Allergy and Immunological Disease, Metropolitan Komagome Hospital, Tokyo, Japan

    Shigeko Inokuma

Authors
  1. Masao Negishi
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  2. Tsuyoshi Kasama
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  3. Ryosuke Hanaoka
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  4. Hirotsugu Ide
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  5. Shigeko Inokuma
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Negishi, M., Kasama, T., Hanaoka, R. et al. Peripheral T cell lymphoma-associated hemophagocytic syndrome in a patient with human adjuvant disease. Rheumatol Int 23, 143–145 (2003). https://doi.org/10.1007/s00296-002-0281-0

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  • DOI: https://doi.org/10.1007/s00296-002-0281-0

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