Abstract
The histone modifications usually form complicated networks to regulate accessibility of DNA and transcription. Identification of proteins that are involved in the crosstalk among different histone modifications will help to better understand the epigenetic regulatory network in eukaryotes. The Inhibitor of Growth (ING) proteins represent a tumor suppressor family were first linked to histone modification in yeast and their functions in epigenetic regulation were further characterized. This review summarizes the crosstalk of histone modification in fungi and describes recently achieved mechanistic insights into the role of Fng1 (an ING protein in filamentous ascomycetes) in this process. We conclude that Fng1 is involved in crosstalk among histone acetylation, deacetylation and methylation.
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Acknowledgements
We thank Dr. Larry Dunkle, Professor Emeritus at Purdue University, for critical reading of this manuscript.
Funding
This work was supported by grants from New Star of Youth Science and Technology of Shaanxi Province (2018KJXX-068).
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CJ and JRX wrote the manuscript. MY, HJ and XF prepared the figure.
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Communicated by Michael Polymenis.
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Ye, M., Jiang, H., Fu, X. et al. Fng1 is involved in crosstalk between histone acetylation and methylation. Curr Genet 67, 535–538 (2021). https://doi.org/10.1007/s00294-021-01167-2
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DOI: https://doi.org/10.1007/s00294-021-01167-2