Current Genetics

, Volume 65, Issue 1, pp 41–55 | Cite as

Protein phosphatases of Saccharomyces cerevisiae

  • Sarah R. Offley
  • Martin C. SchmidtEmail author


The phosphorylation status of a protein is highly regulated and is determined by the opposing activities of protein kinases and protein phosphatases within the cell. While much is known about the protein kinases found in Saccharomyces cerevisiae, the protein phosphatases are much less characterized. Of the 127 protein kinases in yeast, over 90% are in the same evolutionary lineage. In contrast, protein phosphatases are fewer in number (only 43 have been identified in yeast) and comprise multiple, distinct evolutionary lineages. Here we review the protein phosphatase families of yeast with regard to structure, catalytic mechanism, regulation, and signal transduction participation.


Protein phosphatase Convergent evolution Saccharomyces cerevisiae Catalytic mechanism Signal transduction 



This work was supported by National Institutes of Health Grant GM46443.


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© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Microbiology and Molecular GeneticsUniversity of Pittsburgh School of MedicinePittsburghUSA

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