Abstract
Quiescence is operationally characterized as a temporary and reversible proliferation arrest. There are many preconceived ideas about quiescence, quiescent cells being generally viewed as insignificant sleeping G1 cells. In fact, quiescence is central for organism physiology and its dysregulation involved in many pathologies. The quiescent state encompasses very diverse cellular situations depending on the cell type and its environment. This diversity challenges not only quiescence uniformity but also the universality of the molecular mechanisms beyond quiescence regulation. In this mini-perspective, we discuss recent advances in the concept of quiescence, and illustrate that this multifaceted cellular state is gaining increasing attention in many fields of biology.
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Acknowledgements
We express our profound gratitude to B. Daignan-Fornier for precious discussions and comments on this manuscript. DL and IS are supported by the University of Bordeaux and the Centre National de la Recherche Scientifique.
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Sagot, I., Laporte, D. Quiescence, an individual journey. Curr Genet 65, 695–699 (2019). https://doi.org/10.1007/s00294-018-00928-w
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DOI: https://doi.org/10.1007/s00294-018-00928-w