Abstract
Quorum sensing, a form of molecular communication in microbial communities, is relatively well studied in bacterial species, but poorly understood in fungi. Farnesol, a quorum sensing molecule secreted by the opportunistic human pathogenic fungus Candida albicans, was the first quorum sensing molecule described in a eukaryotic organism. However, despite considerable research efforts and advances in recent years, the mechanisms behind its action remain largely elusive. Only recently, we showed that deletion of the C. albicans gene EED1 (eed1Δ), which is essential for hyphal maintenance, resulted in both increased farnesol production and hypersensitivity to farnesol, providing a link between farnesol signaling and elongated hyphal growth. This finding raised several questions concerning farnesol signaling. In this short review we use the unique phenotype of the eed1Δ mutant to summarize current hypotheses and to speculate on possible mechanisms of quorum sensing in C. albicans and its implication in fungus–host interaction, by drawing comparisons to comparatively well-studied quorum sensing systems in bacteria.
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References
Abe S et al (2009) Suppression of anti-Candida activity of macrophages by a quorum-sensing molecule, farnesol, through induction of oxidative stress. Microbiol Immunol 53:323–330. doi:10.1111/j.1348-0421.2009.00128.x
Albuquerque P, Casadevall A (2012) Quorum sensing in fungi: a review. Med Mycol 50:337–345. doi:10.3109/13693786.2011.652201
Allison DL, Willems HM, Jayatilake JA, Bruno VM, Peters BM, Shirtliff ME (2016) Candida-bacteria interactions: their impact on human disease Microbiol Spectr. doi:10.1128/microbiolspec.VMBF-0030-2016
Antunes LC, Ferreira RB, Buckner MM, Finlay BB (2010) Quorum sensing in bacterial virulence. Microbiology 156:2271–2282. doi:10.1099/mic.0.038794-0
Balaban N et al (2007) Treatment of Staphylococcus aureus biofilm infection by the quorum-sensing inhibitor RIP. Antimicrob Agents Chemother 51:2226–2229. doi:10.1128/AAC.01097-06
Bassler BL (2002) Small talk. Cell-to-cell communication in bacteria. Cell 109:421–424
Bassler BL, Wright M, Showalter RE, Silverman MR (1993) Intercellular signalling in Vibrio harveyi: sequence and function of genes regulating expression of luminescence. Mol Microbiol 9:773–786
Biswas S, Van Dijck P, Datta A (2007) Environmental sensing and signal transduction pathways regulating morphopathogenic determinants of Candida albicans. Microbiol Mol Biol Rev 71:348–376. doi:10.1128/MMBR.00009-06
Boles BR, Horswill AR (2008) Agr-mediated dispersal of Staphylococcus aureus biofilms. PLoS Pathog 4:e1000052. doi:10.1371/journal.ppat.1000052
Brand A, Barnes JD, Mackenzie KS, Odds FC, Gow NA (2008) Cell wall glycans and soluble factors determine the interactions between the hyphae of Candida albicans and Pseudomonas aeruginosa. FEMS Microbiol Lett 287:48–55. doi:10.1111/j.1574-6968.2008.01301.x
Bringmann A, Skatchkov SN, Faude F, Enzmann V, Reichenbach A (2000) Farnesol modulates membrane currents in human retinal glial cells. J Neurosci Res 62:396–402. doi:10.1002/1097-4547(20001101)62:3<396::AID-JNR10>3.0.CO;2-E
Cao JG, Meighen EA (1989) Purification and structural identification of an autoinducer for the luminescence system of Vibrio harveyi. J Biol Chem 264:21670–21676
Cao YY et al (2005) cDNA microarray analysis of differential gene expression in Candida albicans biofilm exposed to farnesol. Antimicrob Agents Chemother 49:584–589. doi:10.1128/AAC.49.2.584-589.2005
Castillo-Juarez I et al (2015) Role of quorum sensing in bacterial infections. World J Clin Cases 3:575–598
Chang W, Li Y, Zhang L, Cheng A, Lou H (2012) Retigeric acid B attenuates the virulence of Candida albicans via inhibiting adenylyl cyclase activity targeted by enhanced farnesol production. PLoS One 7:e41624. doi:10.1371/journal.pone.0041624
Cho T, Aoyama T, Toyoda M, Nakayama H, Chibana H, Kaminishi H (2007) Transcriptional changes in Candida albicans genes by both farnesol and high cell density at an early stage of morphogenesis in N-acetyl-D-glucosamine medium Nihon Ishinkin Gakkai Zasshi 48:159–167
Cordeiro RA et al (2013) Minimum inhibitory concentrations of amphotericin B, azoles and caspofungin against Candida species are reduced by farnesol. Med Mycol 51:53–59. doi:10.3109/13693786.2012.692489
Cugini C, Calfee MW, Farrow JM 3rd, Morales DK, Pesci EC, Hogan DA (2007) Farnesol, a common sesquiterpene, inhibits PQS production in Pseudomonas aeruginosa. Mol Microbiol 65:896–906. doi:10.1111/j.1365-2958.2007.05840.x
Cugini C, Morales DK, Hogan DA (2010) Candida albicans-produced farnesol stimulates Pseudomonas quinolone signal production in LasR-defective Pseudomonas aeruginosa strains. Microbiology 156:3096–3107. doi:10.1099/mic.0.037911-0
Davis-Hanna A, Piispanen AE, Stateva LI, Hogan DA (2008) Farnesol and dodecanol effects on the Candida albicans Ras1-cAMP signalling pathway and the regulation of morphogenesis. Mol Microbiol 67:47–62. doi:10.1111/j.1365-2958.2007.06013.x
Deveau A, Piispanen AE, Jackson AA, Hogan DA (2010) Farnesol induces hydrogen peroxide resistance in Candida albicans yeast by inhibiting the Ras-cyclic AMP signaling pathway. Eukaryot Cell 9:569–577. doi:10.1128/EC.00321-09
Dichtl K, Ebel F, Dirr F, Routier FH, Heesemann J, Wagener J (2010) Farnesol misplaces tip-localized Rho proteins and inhibits cell wall integrity signalling in Aspergillus fumigatus. Mol Microbiol 76:1191–1204. doi:10.1111/j.1365-2958.2010.07170.x
Dixon EF, Hall RA (2015) Noisy neighbourhoods: quorum sensing in fungal-polymicrobial infections. Cell Microbiol 17:1431–1441. doi:10.1111/cmi.12490
Du H, Huang G (2016) Environmental pH adaption and morphological transitions in Candida albicans. Curr Genet 62:283–286. doi:10.1007/s00294-015-0540-8
Enjalbert B, Whiteway M (2005) Release from quorum-sensing molecules triggers hyphal formation during Candida albicans resumption of growth. Eukaryot Cell 4:1203–1210. doi:10.1128/EC.4.7.1203-1210.2005
Favre-Bonte S, Pache JC, Robert J, Blanc D, Pechere JC, van Delden C (2002) Detection of Pseudomonas aeruginosa cell-to-cell signals in lung tissue of cystic fibrosis patients. Microb Pathog 32:143–147. doi:10.1006/mpat.2001.0487
Fuqua WC, Winans SC, Greenberg EP (1994) Quorum sensing in bacteria: the LuxR-LuxI family of cell density-responsive transcriptional regulators. J Bacteriol 176:269–275
Ganguly S et al (2011) Zap1 control of cell-cell signaling in Candida albicans biofilms. Eukaryot Cell 10:1448–1454. doi:10.1128/EC.05196-11
Geisenberger O, Givskov M, Riedel K, Hoiby N, Tummler B, Eberl L (2000) Production of N-acyl-l-homoserine lactones by P. aeruginosa isolates from chronic lung infections associated with cystic fibrosis. FEMS Microbiol Lett 184:273–278
Ghosh S, Howe N, Volk K, Tati S, Nickerson KW, Petro TM (2010) Candida albicans cell wall components and farnesol stimulate the expression of both inflammatory and regulatory cytokines in the murine RAW264.7 macrophage cell line. FEMS Immunol Med Microbiol 60:63–73. doi:10.1111/j.1574-695X.2010.00717.x
Hall RA et al (2011) The quorum-sensing molecules farnesol/homoserine lactone and dodecanol operate via distinct modes of action in Candida albicans. Eukaryot Cell 10:1034–1042. doi:10.1128/EC.05060-11
Hawver LA, Jung SA, Ng WL (2016) Specificity and complexity in bacterial quorum-sensing systems. FEMS Microbiol Rev 40:738–752. doi:10.1093/femsre/fuw014
Hazen KC, Cutler JE (1979) Autoregulation of germ tube formation by Candida albicans. Infect Immun 24:661–666
Hogan DA (2006) Talking to themselves: autoregulation and quorum sensing in fungi. Eukaryot Cell 5:613–619. doi:10.1128/EC.5.4.613-619.2006
Hogan DA, Kolter R (2002) Pseudomonas-Candida interactions: an ecological role for virulence factors. Science 296:2229–2232. doi:10.1126/science.1070784
Hogan DA, Vik A, Kolter R (2004) A Pseudomonas aeruginosa quorum-sensing molecule influences Candida albicans morphology. Mol Microbiol 54:1212–1223. doi:10.1111/j.1365-2958.2004.04349.x
Hornby JM et al (2001) Quorum sensing in the dimorphic fungus Candida albicans is mediated by farnesol. Appl Environ Microbiol 67:2982–2992. doi:10.1128/AEM.67.7.2982-2992.2001
Hornby JM, Kebaara BW, Nickerson KW (2003) Farnesol biosynthesis in Candida albicans: cellular response to sterol inhibition by zaragozic acid B. Antimicrob Agents Chemother 47:2366–2369
Jabra-Rizk MA, Meiller TF, James CE, Shirtliff ME (2006) Effect of farnesol on Staphylococcus aureus biofilm formation and antimicrobial susceptibility. Antimicrob Agents Chemother 50:1463–1469. doi:10.1128/AAC.50.4.1463-1469.2006
Jensen V et al (2006) RhlR expression in Pseudomonas aeruginosa is modulated by the Pseudomonas quinolone signal via PhoB-dependent and -independent pathways. J Bacteriol 188:8601–8606. doi:10.1128/JB.01378-06
Jimenez JC, Federle MJ (2014) Quorum sensing in group A Streptococcus Front Cell Infect Microbiol 4:127 doi:10.3389/fcimb.2014.00127
Joo JH, Jetten AM (2010) Molecular mechanisms involved in farnesol-induced apoptosis. Cancer Lett 287:123–135. doi:10.1016/j.canlet.2009.05.015
Jung SA, Chapman CA, Ng WL (2015) Quadruple quorum-sensing inputs control Vibrio cholerae virulence and maintain system robustness. PLoS Pathog 11:e1004837. doi:10.1371/journal.ppat.1004837
Jung SA, Hawver LA, Ng WL (2016) Parallel quorum sensing signaling pathways in Vibrio cholerae. Curr Genet 62:255–260. doi:10.1007/s00294-015-0532-8
Katragkou A et al (2015) In vitro interactions between farnesol and fluconazole, amphotericin B or micafungin against Candida albicans biofilms. J Antimicrob Chemother 70:470–478. doi:10.1093/jac/dku374
Kebaara BW, Langford ML, Navarathna DH, Dumitru R, Nickerson KW, Atkin AL (2008) Candida albicans Tup1 is involved in farnesol-mediated inhibition of filamentous-growth induction. Eukaryot Cell 7:980–987. doi:10.1128/EC.00357-07
Kim J, Sudbery P (2011) Candida albicans, a major human fungal pathogen. J Microbiol 49:171–177. doi:10.1007/s12275-011-1064-7
Kimura N (2014) Metagenomic approaches to understanding phylogenetic diversity in quorum sensing. Virulence 5:433–442. doi:10.4161/viru.27850
Kruppa M, Krom BP, Chauhan N, Bambach AV, Cihlar RL, Calderone RA (2004) The two-component signal transduction protein Chk1p regulates quorum sensing in Candida albicans. Eukaryot Cell 3:1062–1065. doi:10.1128/EC.3.4.1062-1065.2004
Kumamoto CA, Vinces MD (2005) Contributions of hyphae and hypha-co-regulated genes to Candida albicans virulence. Cell Microbiol 7:1546–1554. doi:10.1111/j.1462-5822.2005.00616.x
Langford ML, Atkin AL, Nickerson KW (2009) Cellular interactions of farnesol, a quorum-sensing molecule produced by Candida albicans. Future Microbiol 4:1353–1362. doi:10.2217/fmb.09.98
Langford ML, Hasim S, Nickerson KW, Atkin AL (2010) Activity and toxicity of farnesol towards Candida albicans are dependent on growth conditions. Antimicrob Agents Chemother 54:940–942. doi:10.1128/AAC.01214-09
Langford ML et al (2013) Candida albicans Czf1 and Efg1 coordinate the response to farnesol during quorum sensing, white-opaque thermal dimorphism, and cell death. Eukaryot Cell 12:1281–1292. doi:10.1128/EC.00311-12
LaSarre B, Federle MJ (2013) Exploiting quorum sensing to confuse bacterial pathogens. Microbiol Mol Biol Rev 77:73–111. doi:10.1128/MMBR.00046-12
Lee J, Zhang L (2015) The hierarchy quorum sensing network in Pseudomonas aeruginosa. Protein Cell 6:26–41. doi:10.1007/s13238-014-0100-x
Leger T, Garcia C, Ounissi M, Lelandais G, Camadro JM (2015) The metacaspase (Mca1p) has a dual role in farnesol-induced apoptosis in Candida albicans. Mol Cell Proteomics 14:93–108. doi:10.1074/mcp.M114.041210
Leonhardt I et al. (2015) The fungal quorum-sensing molecule farnesol activates innate immune cells but suppresses cellular adaptive immunity MBio 6:e00143 doi:10.1128/mBio.00143-15
Lina G et al (1998) Transmembrane topology and histidine protein kinase activity of AgrC, the agr signal receptor in Staphylococcus aureus. Mol Microbiol 28:655–662
Lindsay AK, Deveau A, Piispanen AE, Hogan DA (2012) Farnesol and cyclic AMP signaling effects on the hypha-to-yeast transition in Candida albicans. Eukaryot Cell 11:1219–1225. doi:10.1128/EC.00144-12
Machida K, Tanaka T (1999) Farnesol-induced generation of reactive oxygen species dependent on mitochondrial transmembrane potential hyperpolarization mediated by F(0)F(1)-ATPase in yeast. FEBS Lett 462:108–112
Martin R et al (2011) The Candida albicans-specific gene EED1 encodes a key regulator of hyphal extension. PLoS One 6:e18394. doi:10.1371/journal.pone.0018394
McAlester G, O’Gara F, Morrissey JP (2008) Signal-mediated interactions between Pseudomonas aeruginosa and Candida albicans. J Med Microbiol 57:563–569. doi:10.1099/jmm.0.47705-0
Mear JB, Kipnis E, Faure E, Dessein R, Schurtz G, Faure K, Guery B (2013) Candida albicans and Pseudomonas aeruginosa interactions: more than an opportunistic criminal association? Med Mal Infect 43:146–151. doi:10.1016/j.medmal.2013.02.005
Miller MB, Bassler BL (2001) Quorum sensing in bacteria. Annu Rev Microbiol 55:165–199. doi:10.1146/annurev.micro.55.1.165
Monnet V, Juillard V, Gardan R (2014) Peptide conversations in Gram-positive bacteria. Crit Rev Microbiol 42:339–351. doi:10.3109/1040841X.2014.948804
Morales DK, Jacobs NJ, Rajamani S, Krishnamurthy M, Cubillos-Ruiz JR, Hogan DA (2010) Antifungal mechanisms by which a novel Pseudomonas aeruginosa phenazine toxin kills Candida albicans in biofilms. Mol Microbiol 78:1379–1392. doi:10.1111/j.1365-2958.2010.07414.x
Morales DK, Grahl N, Okegbe C, Dietrich LE, Jacobs NJ, Hogan DA (2013) Control of Candida albicans metabolism and biofilm formation by Pseudomonas aeruginosa phenazines MBio 4:e00526–00512 doi:10.1128/mBio.00526-12
Moyes DL et al (2010) A biphasic innate immune MAPK response discriminates between the yeast and hyphal forms of Candida albicans in epithelial cells. Cell Host Microbe 8:225–235. doi:10.1016/j.chom.2010.08.002
Navarathna DH, Hornby JM, Hoerrmann N, Parkhurst AM, Duhamel GE, Nickerson KW (2005) Enhanced pathogenicity of Candida albicans pre-treated with subinhibitory concentrations of fluconazole in a mouse model of disseminated candidiasis. J Antimicrob Chemother 56:1156–1159. doi:10.1093/jac/dki383
Navarathna DH, Hornby JM, Krishnan N, Parkhurst A, Duhamel GE, Nickerson KW (2007a) Effect of farnesol on a mouse model of systemic candidiasis, determined by use of a DPP3 knockout mutant of Candida albicans. Infect Immun 75:1609–1618. doi:10.1128/IAI.01182-06
Navarathna DH, Nickerson KW, Duhamel GE, Jerrels TR, Petro TM (2007b) Exogenous farnesol interferes with the normal progression of cytokine expression during candidiasis in a mouse model. Infect Immun 75:4006–4011. doi:10.1128/IAI.00397-07
Nealson KH, Platt T, Hastings JW (1970) Cellular control of the synthesis and activity of the bacterial luminescent system. J Bacteriol 104:313–322
Nickerson KW, Atkin AL (2016) Deciphering fungal dimorphism: farnesol’s unanswered questions. Mol Microbiol. doi:10.1111/mmi.13601 [Epub ahead of print]
Nickerson KW, Atkin AL, Hornby JM (2006) Quorum sensing in dimorphic fungi: farnesol and beyond. Appl Environ Microbiol 72:3805–3813. doi:10.1128/AEM.02765-05
Nickerson K, Atkin A, Hargarten J, Pathirana R, Hasim S (2012) Thoughts on quorum sensing and fungal dimorphism. In: Witzany G (ed) Biocommunication of Fungi. Springer Netherlands, Dordrecht, pp 189–204
Niu C, Afre S, Gilbert ES (2006) Subinhibitory concentrations of cinnamaldehyde interfere with quorum sensing. Lett Appl Microbiol 43:489–494. doi:10.1111/j.1472-765X.2006.02001.x
Odds FC (1987) Candida infections: an overview. Crit Rev Microbiol 15:1–5. doi:10.3109/10408418709104444
Parmryd I, Dallner G (1996) Organization of isoprenoid biosynthesis. Biochem Soc Trans 24:677–682
Pearson JP, Van Delden C, Iglewski BH (1999) Active efflux and diffusion are involved in transport of Pseudomonas aeruginosa cell-to-cell signals. J Bacteriol 181:1203–1210
Pierce JV, Kumamoto CA (2012) Variation in Candida albicans EFG1 expression enables host-dependent changes in colonizing fungal populations MBio 3:e00117–00112 doi:10.1128/mBio.00117-12
Piispanen AE, Grahl N, Hollomon JM, Hogan DA (2013) Regulated proteolysis of Candida albicans Ras1 is involved in morphogenesis and quorum sensing regulation. Mol Microbiol 89:166–178. doi:10.1111/mmi.12268
Polke M et al (2016) A functional link between hyphal maintenance and quorum sensing in Candida albicans. Mol Microbiol. doi:10.1111/mmi.13526 [Epub ahead of print]
Pollak S, Omer Bendori S, Eldar A (2015) A complex path for domestication of B. subtilis sociality. Curr Genet 61:493–496. doi:10.1007/s00294-015-0479-9
Ramage G, Saville SP, Wickes BL, Lopez-Ribot JL (2002) Inhibition of Candida albicans biofilm formation by farnesol, a quorum-sensing molecule. Appl Environ Microbiol 68:5459–5463
Roman E, Alonso-Monge R, Gong Q, Li D, Calderone R, Pla J (2009) The Cek1 MAPK is a short-lived protein regulated by quorum sensing in the fungal pathogen Candida albicans. FEMS Yeast Res 9:942–955. doi:10.1111/j.1567-1364.2009.00545.x
Rutherford ST, Bassler BL (2012) Bacterial quorum sensing: its role in virulence and possibilities for its control Cold Spring Harb Perspect Med 2
Ryan RP, Dow JM (2011) Communication with a growing family: diffusible signal factor (DSF) signaling in bacteria. Trends Microbiol 19:145–152. doi:10.1016/j.tim.2010.12.003
Sappington KJ, Dandekar AA, Oinuma K, Greenberg EP (2011) Reversible signal binding by the Pseudomonas aeruginosa quorum-sensing signal receptor LasR MBio 2:e00011–00011
Sarkisova SA, Lotlikar SR, Guragain M, Kubat R, Cloud J, Franklin MJ, Patrauchan MA (2014) A Pseudomonas aeruginosa EF-hand protein, EfhP (PA4107), modulates stress responses and virulence at high calcium concentration. PLoS One 9:e98985. doi:10.1371/journal.pone.0098985
Scheper MA, Shirtliff ME, Meiller TF, Peters BM, Jabra-Rizk MA (2008) Farnesol, a fungal quorum-sensing molecule triggers apoptosis in human oral squamous carcinoma cells. Neoplasia 10:954–963
Schramm VL et al (2008) Transition state analogues in quorum sensing and SAM recycling. Nucleic Acids Symp Ser (Oxf). doi:10.1093/nass/nrn038
Scutera S, Zucca M, Savoia D (2014) Novel approaches for the design and discovery of quorum-sensing inhibitors. Expert Opin Drug Discov 9:353–366 doi:10.1517/17460441.2014.894974
Sharma R, Jangid K (2014) Fungal Quorum Sensing Inhibitors. In: Kalia VC (ed) Quorum sensing vs quorum quenching: a battle with no end in sight. Springer India, New Delhi, pp 237–257. doi:10.1007/978-81-322-1982-8_20
Shirtliff ME et al (2009a) Farnesol-induced apoptosis in Candida albicans. Antimicrob Agents Chemother 53:2392–2401. doi:10.1128/AAC.01551-08
Shirtliff ME, Peters BM, Jabra-Rizk MA (2009b) Cross-kingdom interactions: Candida albicans and bacteria. FEMS Microbiol Lett 299:1–8. doi:10.1111/j.1574-6968.2009.01668.x
Singh PK, Schaefer AL, Parsek MR, Moninger TO, Welsh MJ, Greenberg EP (2000) Quorum-sensing signals indicate that cystic fibrosis lungs are infected with bacterial biofilms. Nature 407:762–764. doi:10.1038/35037627
Sudbery PE (2011) Growth of Candida albicans hyphae. Nat Rev Microbiol 9:737–748. doi:10.1038/nrmicro2636
Sun J, Daniel R, Wagner-Dobler I, Zeng AP (2004) Is autoinducer-2 a universal signal for interspecies communication: a comparative genomic and phylogenetic analysis of the synthesis and signal transduction pathways. BMC Evol Biol 4:36. doi:10.1186/1471-2148-4-36
Swem LR, Swem DL, Wingreen NS, Bassler BL (2008) Deducing receptor signaling parameters from in vivo analysis: LuxN/AI-1 quorum sensing in Vibrio harveyi. Cell 134:461–473. doi:10.1016/j.cell.2008.06.023
Vuong C, Saenz HL, Gotz F, Otto M (2000) Impact of the agr quorum-sensing system on adherence to polystyrene in Staphylococcus aureus. J Infect Dis 182:1688–1693. doi:10.1086/317606
Waters CM, Bassler BL (2005) Quorum sensing: cell-to-cell communication in bacteria. Annu Rev Cell Dev Biol 21:319–346. doi:10.1146/annurev.cellbio.21.012704.131001
White SJ et al (2007) Self-regulation of Candida albicans population size during GI colonization. PLoS Pathog 3:e184. doi:10.1371/journal.ppat.0030184
Williams P et al (2000) Quorum sensing and the population-dependent control of virulence. Philos Trans R Soc Lond B Biol Sci 355:667–680. doi:10.1098/rstb.2000.0607
Winstanley C, Fothergill JL (2009) The role of quorum sensing in chronic cystic fibrosis Pseudomonas aeruginosa infections. FEMS Microbiol Lett 290:1–9. doi:10.1111/j.1574-6968.2008.01394.x
Yada S, Kamalesh B, Sonwane S, Guptha I, Swetha RK (2015) Quorum sensing inhibition, relevance to periodontics J Int Oral. Health (London) 7:67–69
Yang N, Lan L (2016) Pseudomonas aeruginosa Lon and ClpXP proteases: roles in linking carbon catabolite repression system with quorum-sensing system. Curr Genet 62:1–6. doi:10.1007/s00294-015-0499-5
Yarwood JM, Bartels DJ, Volper EM, Greenberg EP (2004) Quorum sensing in Staphylococcus aureus biofilms. J Bacteriol 186:1838–1850
Yen CM, Howard DH (1970) Germination of blastospores of Histoplasma capslatum. Sabouraudia 8:242–252
Yu LH, Wei X, Ma M, Chen XJ, Xu SB (2012) Possible inhibitory molecular mechanism of farnesol on the development of fluconazole resistance in Candida albicans biofilm. Antimicrob Agents Chemother 56:770–775. doi:10.1128/AAC.05290-11
Zakikhany K, Naglik JR, Schmidt-Westhausen A, Holland G, Schaller M, Hube B (2007) In vivo transcript profiling of Candida albicans identifies a gene essential for interepithelial dissemination. Cell Microbiol 9:2938–2954. doi:10.1111/j.1462-5822.2007.01009.x
Zhang L, Chang W, Sun B, Groh M, Speicher A, Lou H (2011) Bisbibenzyls, a new type of antifungal agent, inhibit morphogenesis switch and biofilm formation through upregulation of DPP3 in Candida albicans. PLoS One 6:e28953. doi:10.1371/journal.pone.0028953
Zhu J et al (2011) Farnesol-induced apoptosis in Candida albicans is mediated by Cdr1-p extrusion and depletion of intracellular glutathione. PLoS One 6:e28830. doi:10.1371/journal.pone.0028830
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This work was financially supported by the Studienstiftung des deutschen Volkes e.V. (to MP) and the Deutsche Forschungsgemeinschaft (DFG JA1960/1-1, to IDJ).
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Polke, M., Jacobsen, I.D. Quorum sensing by farnesol revisited. Curr Genet 63, 791–797 (2017). https://doi.org/10.1007/s00294-017-0683-x
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DOI: https://doi.org/10.1007/s00294-017-0683-x