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Current Genetics

, Volume 63, Issue 1, pp 79–90 | Cite as

The cell envelope stress response of Bacillus subtilis: from static signaling devices to dynamic regulatory network

  • Jara Radeck
  • Georg Fritz
  • Thorsten MascherEmail author
Review

Abstract

The cell envelope stress response (CESR) encompasses all regulatory events that enable a cell to protect the integrity of its envelope, an essential structure of any bacterial cell. The underlying signaling network is particularly well understood in the Gram-positive model organism Bacillus subtilis. It consists of a number of two-component systems (2CS) and extracytoplasmic function σ factors that together regulate the production of both specific resistance determinants and general mechanisms to protect the envelope against antimicrobial peptides targeting the biogenesis of the cell wall. Here, we summarize the current picture of the B. subtilis CESR network, from the initial identification of the corresponding signaling devices to unraveling their interdependence and the underlying regulatory hierarchy within the network. In the course of detailed mechanistic studies, a number of novel signaling features could be described for the 2CSs involved in mediating CESR. This includes a novel class of so-called intramembrane-sensing histidine kinases (IM-HKs), which—instead of acting as stress sensors themselves—are activated via interprotein signal transfer. Some of these IM-HKs are involved in sensing the flux of antibiotic resistance transporters, a unique mechanism of responding to extracellular antibiotic challenge.

Keywords

Cell wall antibiotic ECF sigma factor Lipid II cycle Stress response Signal transduction Two-component system 

Notes

Acknowledgments

The authors would like to acknowledge the contributions of numerous co-workers of the Mascher group, who by their dedication, hard work and intellectual input shaped our picture of the cell envelope stress response of B. subtilis in the past decade.

Compliance with ethical standards

Funding

Work on the cell envelope stress response of B. subtilis in the Mascher and Fritz groups was continuously supported by Grants from the Deutsche Forschungsgemeinschaft (DFG) (Grants MA 3269, MA2837/1-3, and MA2837/3-1 to TM as well as Grant FR 3673/1-2 to GF).

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  1. 1.Institute of MicrobiologyTechnische Universität (TU) DresdenDresdenGermany
  2. 2.LOEWE-Center for Synthetic Microbiology (SYNMIKRO)Philipps-Universität MarburgMarburgGermany

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