Current Genetics

, Volume 63, Issue 1, pp 29–33 | Cite as

LncRNAs, lost in translation or licence to regulate?

  • Alvaro de Andres-Pablo
  • Antonin Morillon
  • Maxime Wery
Review

Abstract

Over the last decade, advances in transcriptomics have revealed that the pervasive transcription of eukaryotic genomes produces plethora of long noncoding RNAs (lncRNAs), which are now recognized as major regulators of multiple cellular processes. Although they have been thought to lack any protein-coding potential, recent ribosome-profiling data indicate that lncRNAs can interact with the translation machinery, leading to the production of functional peptides in some cases. In this perspective, we have explored the idea that translation can be part of the fate of cytoplasmic lncRNAs, raising the possibility for them to work as bifunctional RNAs, endowed with dual coding and regulatory functions.

Keywords

LncRNA Non-coding genome RNA decay Regulatory RNA Transcription Translation 

Notes

Acknowledgments

We thank all the members of our lab for discussions and critical reading of the manuscript. A. Morillon’s lab is supported by the ANR “DNA-Life” and ERC “DARK” consolidator grants.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  • Alvaro de Andres-Pablo
    • 1
  • Antonin Morillon
    • 1
  • Maxime Wery
    • 1
  1. 1.ncRNA, Epigenetic and Genome Fluidity, Institut CuriePSL Research UniversityParis Cedex 05France

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