Histone-like proteins (HLPs) are small and basic bacterial proteins that are associated with a nucleoid and play roles in maintaining DNA architecture and regulating DNA transactions such as replication, recombination/repair and transcription. The studies on HLPs from a variety of bacterial species in recent years are summarized in this mini-review. A recent study reported a novel DNA-binding protein (HP119) in Helicobacter pylori that shows some HLP features. It plays a large role in aiding bacterial stress resistance. We provide herein additional evidence that HP119 is a nucleoid-associated protein, and present some perspectives for future study.
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This work was supported by The University of Georgia Research Foundation.
Communicated by M. Kupiec.
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Wang, G., Maier, R.J. Bacterial histone-like proteins: roles in stress resistance. Curr Genet 61, 489–492 (2015). https://doi.org/10.1007/s00294-015-0478-x
- Histone-like proteins
- Helicobacter pylori
- Stress resistance