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Periphere neuroblastische Tumoren im Kindesalter

Peripheral neuroblastic tumors in childhood

  • Schwerpunkt: Kindliche Tumoren
  • Published:
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Zusammenfassung

Periphere neuroblastäre Tumoren sind die viertgrößte Gruppe maligner Tumoren im Kindesalter. Den weitaus größten Anteil dieser Tumoren bildet das Neuroblastom mit den Subtypen des undifferenzierten, des gering differenzierten und des differenzierenden Neuroblastoms. Außerdem gehören das Ganglioneuroblastom, ein Komposittumor aus Schwann-Zell-Stroma und Neuroblasten sowie das benigne Ganglioneurom zu den peripheren neuroblastischen Tumoren. Im Rahmen dieser Übersicht werden histopathologische Diagnosekriterien und Graduierungssysteme sowie häufige, prognostisch und therapeutisch relevante molekulare Veränderungen erläutert.

Abstract

Peripheral neuroblastic tumors represent the fourth-largest group of malignant tumors in childhood. The majority of these tumors are neuroblastomas, which can be classified into undifferentiated, poorly differentiated, and differentiating subtypes. In addition, peripheral neuroblastic tumors include ganglioneuroblastoma, a composite tumor composed of Schwannian cell stroma and neuroblasts as well as benign ganglioneuroma. In this overview, histopathological diagnostic criteria and grading systems, as well as common molecular alterations that are of prognostic and therapeutic significance, are discussed.

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Authors and Affiliations

  1. Sektion Kinderpathologie, Institut für Pathologie, Universitätsklinikum Bonn, Venusberg-Campus 1, Gebäude 62, 53127, Bonn, Deutschland

    Marit Bernhardt & Christian Vokuhl

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  1. Marit Bernhardt
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  2. Christian Vokuhl
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Correspondence to Marit Bernhardt.

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M. Bernhardt und C. Vokuhl geben an, dass kein Interessenkonflikt besteht.

Für diesen Beitrag wurden von den Autor/-innen keine Studien an Menschen oder Tieren durchgeführt. Für die aufgeführten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.

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Christian Vokuhl, Bonn

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Bernhardt, M., Vokuhl, C. Periphere neuroblastische Tumoren im Kindesalter. Pathologie 44, 366–372 (2023). https://doi.org/10.1007/s00292-023-01227-z

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