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Epitheliale kindliche Lebertumoren

Eine Übersicht der neuen WHO-Klassifikation für pädiatrische Tumoren

Epithelial childhood liver tumors

An overview of the new WHO classification for pediatric tumors

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Zusammenfassung

Kindliche Lebertumoren sind sehr seltene Tumoren, welche unter 1 % aller kindlichen Malignome ausmachen. Die häufigsten Tumoren im Bereich der Leber stellen Hepatoblastome dar. Im Rahmen dieser Übersicht sollen die epithelialen malignen kindlichen Lebertumoren besprochen werden, wobei insbesondere auf die Morphologie der verschiedenen Hepatoblastomsubtypen eingegangen wird. Zudem werden die anderen malignen Lebertumoren wie der sog. hepatozelluläre Tumor, NOS, sowie der zweithäufigste kindliche Lebertumor, das hepatozelluläre Karzinom, besprochen. Neben den typischen morphologischen Charakteristika werden auch die immunhistochemischen und molekularen Aspekte behandelt, welche helfen können, diese sich teils deutlich ähnelnden Entitäten zu unterscheiden.

Abstract

Pediatric liver tumors are very rare tumors and account for less than 1% of all childhood malignancies. By far the most common tumors are hepatoblastomas. This review discusses epithelial malignant childhood liver tumors, with particular attention to the morphology of the different hepatoblastoma subtypes. In addition, other malignant liver tumors such as the so-called hepatocellular tumor NOS and the second-most common childhood liver tumor, the hepatocellular carcinoma, are discussed. In addition to the typical morphological characteristics, the immunohistochemical and molecular aspects are also be presented, which can help to distinguish these entities with often overlapping morphology.

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Authors and Affiliations

  1. Sektion Kinderpathologie, Institut für Pathologie, Universitätsklinikum Bonn, Venusberg-Campus 1, 53127, Bonn, Deutschland

    J. F. Lau &  C. Vokuhl

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  1. J. F. Lau
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  2. C. Vokuhl
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Correspondence to C. Vokuhl.

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Interessenkonflikt

J.F. Lau und C. Vokuhl geben an, dass kein Interessenkonflikt besteht.

Für diesen Beitrag wurden von den Autoren keine Studien an Menschen oder Tieren durchgeführt. Für die aufgeführten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.

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E. Wardelmann, Münster

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Lau, J.F., Vokuhl, C. Epitheliale kindliche Lebertumoren. Pathologe 43, 202–209 (2022). https://doi.org/10.1007/s00292-022-01067-3

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