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Prognostische Bedeutung von Immunzellinfiltraten in der Tumorpathologie

Prognostic significance of immune cell infiltrates in tumor pathology

Der Pathologe volume 39, pages 532–538 (2018)Cite this article

Zusammenfassung

Hintergrund

Menge, Verteilung, Aktivierungsstatus, Zytokinprofile und Zusammensetzung von Immunzellen in soliden Tumoren sind prognostisch relevant und möglicherweise prädiktiv für das Ansprechen auf Immuntherapeutika.

Fragestellung

Übersicht über relevante Immunzellpopulationen und deren prognostische Bedeutung in den häufigsten Tumorarten.

Methoden

Nicht systematische Erfassung und Diskussion von Studien zur prognostischen Bedeutung einzelner Immunzellpopulationen und der hierfür verwendeten methodischen Ansätze.

Ergebnisse

Über mehrere Tumorentitäten hinweg können prognostisch günstige und ungünstige Immunzellpopulationen differenziert werden. Häufig kommen jedoch unspezifische Zellmarker zum Einsatz, die teils funktionell antagonistische Subpopulationen zusammenfassen. Weiterhin limitieren Unterschiede bei der Probenentnahme und Festlegung der Cut-off-Werte die Vergleichbarkeit der bisher durchgeführten Studien.

Schlussfolgerung

Die phänotypische und funktionelle Heterogenität von tumorassoziierten Immunzellen erfordert den Einsatz spezifischer Antikörper und Antikörperkombinationen. Weiterhin stellen vereinheitlichte Auswerteroutinen, Validierungsstudien und Metaanalysen wichtige Vorbedingungen für eine potenzielle diagnostische Implementierung dar.

Abstract

Background

The quantity, distribution, activation status, cytokine profile, and spatial distribution of tumor-infiltrating immune cells have prognostic value and may be predictive of response to immunotherapies.

Objectives

A survey of relevant immune cell populations including their prognostic significance in the most common types of tumors.

Methods

Nonsystematic assessment and a discussion of studies that were conducted to estimate the prognostic significance of certain immune cell subsets and the methodical approaches used.

Results

For many tumor entities, prognostically favorable and unfavorable immune cell populations can be differentiated. However, nonspecific cell markers that may partly summarize antithetic immune cell subsets can be employed. Differences in sampling procedures and the determination of cut-off levels further limit the comparability of the studies carried out so far.

Conclusion

The phenotypic and functional heterogeneity of tumor-infiltrating immune cells requires the use of cell subset-specific antibodies and antibody combinations. Furthermore, harmonized assessment routines, validation studies, and meta-analyses are important prerequisites for potential diagnostic implementation.

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Affiliations

  1. Institut für Pathologie, Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Langenbeckstr. 1, 55131, Mainz, Deutschland

    D.-C. Wagner & W. Roth

Authors
  1. D.-C. Wagner
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  2. W. Roth
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Corresponding author

Correspondence to D.-C. Wagner.

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Interessenkonflikt

D.-C. Wagner und W. Roth geben an, dass kein Interessenkonflikt besteht.

Dieser Beitrag beinhaltet keine von den Autoren durchgeführten Studien an Menschen oder Tieren.

Additional information

Schwerpunktherausgeber

W. Roth, Mainz

Caption Electronic Supplementary Material

292_2018_541_MOESM1_ESM.pdf

Tab. 1: Detaillierte Auflistung der nicht systematischen Literaturübersicht zum prognostischen Einfluss verschiedener Immunzellen in den zehn häufigsten Tumorentitäten

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Wagner, DC., Roth, W. Prognostische Bedeutung von Immunzellinfiltraten in der Tumorpathologie. Pathologe 39, 532–538 (2018). https://doi.org/10.1007/s00292-018-0541-8

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  • DOI: https://doi.org/10.1007/s00292-018-0541-8

Schlüsselwörter

  • Krebs
  • Immunsystem
  • Leukozyten
  • Prognostische Faktoren
  • Immunhistochemie

Keywords

  • Cancer
  • Immune system
  • Leukocytes
  • Prognostic factors
  • Immunohistochemistry