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Grading von Weichgewebe- und Knochensarkomen

Grading of soft tissue and bone sarcomas

  • Schwerpunkt: Grading-Systeme
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Zusammenfassung

Das Malignitätsgrading stellt einen wesentlichen Baustein bei der Klassifikation von Sarkomen dar. Es korreliert mit der Prognose der Erkrankung und dem Risiko einer Metastasierung. Der Artikel präsentiert die Gradierungsschemata von Sarkomen der Weichteile, des Knochens und des Kindesalters. Die histomorphologischen Kriterien des FNCLCC-Systems (Federation Nationale des Centres de Lutte Contre le Cancer) und der Pediatric Oncology Group werden ebenso vorgestellt wie das Grading von Knochentumoren nach dem System des College of American Pathologists (CAP). Des Weiteren wird aufgezeigt, inwieweit Genexpressionssignaturen („complexity index in sarcoma“, CINSARC) und einzelne genetische Veränderungen (p53, MDM2, p16, SWI/SNF, EWSR1-Fusionen, PAX3/PAX7-FOXO1-Fusionen) für die Prognoseeinschätzung von Sarkomen von Bedeutung sein können.

Abstract

Malignancy grading is an essential element in the classification of sarcomas. It correlates with the prognosis of the disease and the risk of metastasis. This article presents the grading schemes for soft tissue, bone and pediatric sarcomas. It summarizes the histological criteria of the Federation Nationale des Centres de Lutte Contre le Cancer (FNCLCC) system and the Pediatric Oncology Group as well as the grading of bone tumors by the College of American Pathologists (CAP). Furthermore, the potential relevance of gene expression signatures, the complexity index in sarcoma (CINSARC) and single genetic alterations (p53, MDM2, p16, SWI/SNF, EWSR1 fusions and PAX3/PAX7-FOXO1 fusions) for the prognosis of sarcomas are discussed.

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Authors and Affiliations

  1. Institut für Pathologie, Universitätsklinikum Jena, Ziegelmühlenweg 1, 07743, Jena, Deutschland

    I. Petersen

  2. Gerhard-Domagk-Institut für Pathologie, Universitätsklinikum Münster, Münster, Deutschland

    E. Wardelmann

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Correspondence to I. Petersen.

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I. Petersen und E. Wardelmann geben an, dass kein Interessenkonflikt besteht.

Dieser Beitrag beinhaltet keine von den Autoren durchgeführten Studien an Menschen oder Tieren.

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C. Wittekind, Leipzig

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Petersen, I., Wardelmann, E. Grading von Weichgewebe- und Knochensarkomen. Pathologe 37, 320–327 (2016). https://doi.org/10.1007/s00292-016-0184-6

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