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Tumoren des Gonadenstromas

Sex cord gonadal stromal tumors

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Zusammenfassung

Tumoren des Gonadenstromas werden in Leydig-Zell-, Sertoli-Zell-, Granulosazelltumoren, Tumoren der Thekom-Fibrom-Gruppe, inkomplett differenzierte Gonadenstromatumoren, Mischformen von Gonadenstromatumoren und Tumoren aus Elementen von Keimzellen und des Gonadenstromas eingeteilt. Diese Tumoren können sporadisch oder in Assoziation mit genetischen Syndromen auftreten. Zur Diagnostik dieser sehr seltenen Tumoren ist die Kombination aus der Einordnung charakteristischer morphologischer Veränderungen und der Anwendung verschiedener immunhistochemischer Marker hilfreich und wird ergänzt durch neueste molekularpathologische Untersuchungen, die einen möglichen Benefit von Mutationsbestimmungen gezeigt haben.

Abstract

According to the World Health Organization (WHO) classification from 2004, sex cord gonadal stromal tumors are divided into Leydig cell tumors, Sertoli cell tumors, granulosa cell tumors, tumors of the thecoma-fibroma group, incompletely differentiated sex cord gonadal stromal tumors, mixed forms of sex cord gonadal stromal tumors and tumors containing both germ cell and sex cord gonadal stromal elements. These tumors can appear sporadically or in combination with hereditary syndromes. To diagnose these rare tumors the combination of characteristic morphological aspects and various immunohistochemical markers is useful. Latest investigations demonstrate the potential role of mutation analyses in the diagnosis of this heterogeneous group of tumors.

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Einhaltung ethischer Richtlinien

Interessenkonflikt. F. Bremmer, C.L. Behnes, H.-J. Radzun, M. Bettstetter und S. Schweyer geben an, dass kein Interessenkonflikt besteht. Dieser Beitrag beinhaltet keine Studien an Menschen oder Tieren.

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Authors and Affiliations

  1. Institut für Pathologie, Universitätsmedizin Göttingen, Robert-Koch-Str. 40, 37075, Göttingen, Deutschland

    F. Bremmer, C.L. Behnes & H.-J. Radzun

  2. Teilgemeinschaftspraxis Molekularpathologie Südbayern, München, Deutschland

    M. Bettstetter

  3. Gemeinschaftspraxis Pathologie, Starnberg, Deutschland

    S. Schweyer

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  1. F. Bremmer
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  2. C.L. Behnes
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  3. H.-J. Radzun
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  4. M. Bettstetter
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  5. S. Schweyer
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Correspondence to F. Bremmer.

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Bremmer, F., Behnes, C., Radzun, HJ. et al. Tumoren des Gonadenstromas. Pathologe 35, 245–251 (2014). https://doi.org/10.1007/s00292-014-1901-7

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  • DOI: https://doi.org/10.1007/s00292-014-1901-7

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