Zusammenfassung
Im Vergleich zu anderen europäischen und außereuropäischen Ländern werden die Möglichkeiten der Zytopathologie in der Tumordiagnostik an vielen deutschen Pathologie-Instituten traditionell nicht wahrgenommen. Dabei liefern sie gerade dort, wo immunchemische und molekularbiologische Zusatzuntersuchungen angezeigt sind, wertvolles Zellmaterial. Auf vielen Organgebieten kann die Zytologie die histologischen Untersuchungen ergänzen und manche operativen Eingriffe überflüssig machen. Eine Verbesserung der bedauerlichen Situation ist nur möglich, wenn der Zytologie in der Fachausbildung zum Pathologen ein höherer Stellenwert eingeräumt wird. Dies wiederum erfordert organisatorische und infrastrukturelle Veränderungen innerhalb der pathologischen Institute. Dabei sollten die universitären Institute als wichtige Ausbildungsstätten vorangehen.
Abstract
Compared to other European and non-European countries the benefits of cytopathology for the diagnosis of many tumors is still underestimated in Germany for traditional reasons. Cytological methods provide excellent material from many organs for morphological, immunochemical and molecular examinations so that a definitive diagnosis is cytologically possible in many cases and the number of exploratory surgical operations could therefore be reduced. Improvements in this deplorable situation will only be possible if a standardized training period in cytology is consistently included in the training of general pathologists. This requires organizational and infrastructural changes within the institutes of pathology. In this respect, the university institutes as important training institutions should lead the way.
Notes
H.U. Zollinger kommt aber das Verdienst zu, am Basler Universitätsinstitut den Aufbau einer nach wie vor funktionstüchtigen Zytopathologie initiiert und gefördert zu haben.
Literatur
Al-Haddad M, Savabi MS, Sherman S et al (2009) Role of endoscopic ultrasound-guided fine-needle aspiration with flow cytometry to diagnose lymphoma: a single center experience. J Gastroenterol Hepatol 24:1826–1833
Albert U-S, Schulz K-D, Kopp IB (2007) Leitlinien-Methodenreport: Aktualisierung der Stufe-3-Leitlinie Brustkrebsfrüherkennung in Deutschland. - http://www.awmf-leitlinien.de, http://www.senologie.org
Alkuwari E, Auger M (2008) Accuracy of fine-needle aspiration cytology of axillary lymph nodes in breast cancer patients: a study of 115 cases with cytologic-histologic correlation. Cancer 114:89–93
Amador-Ortiz C, Chen L, Hassan A et al (2011) Combined core needle biopsy and fine-needle aspiration with ancillary studies correlate highly with traditional techniques in the diagnosis of nodal-based lymphoma. Am J Clin Pathol 135:516–524
Angelidou E, Politi E, Sotiropoulou G et al (2006) Evaluation of ER, PR, MIB-1, pS2, and nuclear grade in FNA specimens of cT1 breast carcinomas: clinicopathological correlation. Diagn Cytopathol 34:547–552
Barrena S, Almeida J, Del Carmen Garcia-Macias M et al (2011) Flow cytometry immunophenotyping of fine-needle aspiration specimens: utility in the diagnosis and classification of non-Hodgkin lymphomas. Histopathology 58:906–918
Billgren AM, Tani E, Liedberg A et al (2002) Prognostic significance of tumor cell proliferation analyzed in fine needle aspirates from primary breast cancer. Breast Cancer Res Treat 71:161–170
Bode-Lesniewska B (2011) Zytologische Sarkomdiagnostik. Pathologe 32:14–23
Borst M (1928) Infektion und Geschwülste. Münch Med Wschr 33:657, zitiert nach Grunze H, Spriggs AI (1983) History of clinical cytology, 2. Aufl. Giebler, Darmstadt, S 92
Brandao GD, Rose R, McKenzie S et al (2006) Grading follicular lymphomas in fine-needle aspiration biopsies: the role of ThinPrep slides and flow cytometry. Cancer 108:319–323
Bubendorf L, Feichter GE, Obermann EC et al (2010) Zytopathologie. In: Klöppel G, Kreipe HH, Remmele W (Hrsg) Pathologie, 3. Aufl. Springer, Berlin, S 454 f
Caraway NP, Thomas E, Khanna A et al (2008) Chromosomal abnormalities detected by multicolor fluorescence in situ hybridization in fine-needle aspirates from patients with small lymphocytic lymphoma are useful for predicting survival. Cancer 114:315–322
Cunha Santos G da, Ko HM, Geddie WR et al (2010) Targeted use of fluorescence in situ hybridization (FISH) in cytospin preparations: results of 298 fine needle aspirates of B-cell non-Hodgkin lymphoma. Cancer Cytopathol 118:250–258
Demurtas A, Accinelli G, Pacchioni D et al (2010) Utility of flow cytometry immunophenotyping in fine-needle aspirate cytologic diagnosis of non-Hodgkin lymphoma: a series of 252 cases and review of the literature. Appl Immunohistochem Mol Morphol 18:311–322
Feiden W, Steudel WI (1997) Schnellschnittuntersuchungen bei neurochirurgischen Operationen. Pathologe 18:107–110
Gong Y, Yan K, Lin F et al (2007) Determination of oestrogen-receptor status and ERBB2 status of breast carcinoma: a gene-expression profiling study. Lancet Oncol 8:203–211
Hehn ST, Grogan TM, Miller TP (2004) Utility of fine-needle aspiration as a diagnostic technique in lymphoma. J Clin Oncol 22:3046–3052
Layfield LJ (2009) Cytologic diagnosis of osseous lesions: a review with emphasis on the diagnosis of primary neoplasms of bone. Diagn Cytopathol 37:299–310
Lingegowda JB, MuddeGowda PH, Ramakantha CK et al (2011) Cytohistological correlation of grading in breast carcinoma. Diagn Cytopathol 39:251–257
Mayall F, Dray M, Stanley D et al (2000) Immunoflow cytometry and cell block immunohistochemistry in the FNA diagnosis of lymphoma: a review of 73 consecutive cases. J Clin Pathol 53:451–457
Morrison C, Palatini J, Riggenbach J et al (2006) Fine-needle aspiration biopsy of non-Hodgkin lymphoma for use in expression microarray analysis. Cancer 108:311–318
Nassar A (2010) Core needle biopsy versus fine needle aspiration biopsy in breast – a historical perspective and opportunities in the modern era. Diagn Cytopathol 39:380–388
Paleologos TS, Dorward NL, Wadley JP et al (2001) Clinical validation of true frameless stereotactic biopsy: analysis of the first 125 consecutive cases. Neurosurgery 49:830–835, discussion 835–837
Papanicolaou GN (1928) New cancer diagnosis. Proc. 3rd Race Betterment Conference. Battle Creek: 528, zitiert nach Grunze H, Spriggs AI (1983) History of clinical cytology, 2. Aufl. Giebler, Darmstadt, S. 88
Pugh JL, Jhala NC, Eloubeidi MA et al (2006) Diagnosis of deep-seated lymphoma and leukemia by endoscopic ultrasound-guided fine-needle aspiration biopsy. Am J Clin Pathol 125:703–709
Savage EC, Vanderheyden AD, Bell AM et al (2011) Independent diagnostic accuracy of flow cytometry obtained from fine-needle aspirates: a 10-year experience with 451 cases. Am J Clin Pathol 135:304–309
Shabaik A, Lin G, Peterson M et al (2011) Reliability of Her2/neu, estrogen receptor, and progesterone receptor testing by immunohistochemistry on cell block of FNA and serous effusions from patients with primary and metastatic breast carcinoma. Diagn Cytopathol 39:328–332
Stelow EB, Lai R, Bardales RH et al (2004) Endoscopic ultrasound-guided fine-needle aspiration of lymph nodes: the Hennepin County Medical Center experience. Diagn Cytopathol 30:301–306
Swerdlow SW, Campo E, Harris NL et al (2008) WHO classification of tumours of hematopoietic and lymphoid tissue. IARC Press, Lyon
Tilgner J, Herr M, Ostertag C et al (2005) Validation of intraoperative diagnoses using smear preparations from stereotactic brain biopsies: intraoperative versus final diagnosis – influence of clinical factors. Neurosurgery 56:257–65; discussion 257–265
Virchow R (1966) Die Cellularpathologie in ihrer Begründung auf physiologische und pathologische Gewebelehre; zwanzig Vorlesungen gehalten während der Monate Februar, März und April 1858 im pathologischen Institut zu Berlin. (Reprographischer Nachdruck der Berliner Ausgabe von 1858). Georg Olms, Hildesheim, S. 440
Walther C, Domanski HA, Steyern FV von et al (2011) Chromosome banding analysis of cells from fine-needle aspiration biopsy samples from soft tissue and bone tumors: is it clinically meaningful? Cancer Genet 204:203–206
Young NA (2006) Grading follicular lymphoma on fine-needle aspiration specimens – a practical approach. Cancer 108:1–9
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Dalquen, P. Ein Plädoyer für die Zytopathologie. Pathologe 33, 280–285 (2012). https://doi.org/10.1007/s00292-012-1576-x
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DOI: https://doi.org/10.1007/s00292-012-1576-x