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Inflammatorischer fibroider Polyp

Von Vaněks „submukösem Granulom“ zum Konzept einer submukösen mesenchymalen Neoplasie

Inflammatory fibroid polyp

From Vaněk’s “submucosal granuloma” to the concept of submucosal mesenchymal neoplasia

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Zusammenfassung

Inflammatorische fibroide Polypen (IFP) wurden vor 60 Jahren von Vaněk erstmals als „submuköses Granulom mit eosinophiler Infiltration“ beschrieben. IFP stellen polypöse Spindelzellproliferate in der Submukosa und Mukosa von Magen, Dünndarm und Kolon mit entzündlicher Infiltration dar. Die Läsion ist bislang als entzündlich-reaktiv angesehen worden. Neuere Daten zeigen, dass die läsionalen Spindelzellen den PDGFRA exprimieren, in der Mehrzahl der Fälle sind aktivierende PDGFRA-Mutationen nachweisbar. IFP sind also echte benigne mesenchymale Tumoren des Gastrointestinaltrakts.

Abstract

Inflammatory fibroid polyps (IFP) were described by Vaněk 60 years ago as “submucosal granuloma with eosinophilic infiltration”. IFP represent polypous proliferations of spindle cells in the submucosa and mucosa of the stomach, small bowel and colon with inflammatory infiltration. The lesions have been regarded as inflammatory and reactive. Recent data show that the spindle cells express PDGFRA, and the majority of IFP harbour activating PDGFRA mutations. Therefore, IFP represent true benign mesenchymal tumors of the gastrointestinal tract.

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  1. Institut für Pathologie, Universitätsklinikum Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Deutschland

    H.-U. Schildhaus, S. Merkelbach-Bruse, E. Binot, R. Büttner & E. Wardelmann

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  1. H.-U. Schildhaus
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  2. S. Merkelbach-Bruse
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  3. E. Binot
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  4. R. Büttner
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  5. E. Wardelmann
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Correspondence to H.-U. Schildhaus.

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Schildhaus, HU., Merkelbach-Bruse, S., Binot, E. et al. Inflammatorischer fibroider Polyp. Pathologe 31, 109–114 (2010). https://doi.org/10.1007/s00292-009-1254-9

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