Zusammenfassung
Wir berichten über einen ungewöhnlichen Fall eines langjährig klinisch diagnostizierten Warthin-Tumors (WT) mit plötzlicher Größenzunahme und nachfolgender Resektion. Histologisch konnte der WT bestätigt werden, zeigte jedoch zusätzlich diffuse Infiltrate eines dissolut wachsenden Adenokarzinoms. Unter der Annahme eines maligne transformierten WT wurden radiologische Staging-Untersuchungen angeschlossen, mit deren Hilfe ein metastasierendes Mammakarzinom mit identischer Morphologie zu den WT-Infiltraten entdeckt wurde. Die seltene Diagnose eines maligne transformierten WT erfordert daher immer den Ausschluss eines metastasierten Tumorleidens.
Abstract
We present the unusual case of a cytologically diagnosed Warthin tumor (WT) of long standing with sudden enlargement und subsequent resection. Histologically, the diagnosis of WT was confirmed, but the tumor additionally showed diffuse infiltrates of an adenocarcinoma undergoing unrestrained growth. Warthin tumor with malignant transformation was suspected and radiological staging examinations were conducted. PET scans detected a metastasizing carcinoma of the breast, morphologically identical to the WT infiltrates. Care should always be taken when the diagnosis of malignant WT is made to exclude metastatic disease.
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Abbreviations
- CK:
-
Zytokeratin
- CEA:
-
„Carcinoembryonic antigen“
- GCDFP-15:
-
„Gross cystic disease fluid protein 15“
- SMA:
-
„Smooth muscle antigen“
- EBNA:
-
„Epstein-Barr virus nuclear antigen“
- CDX2:
-
„Caudal-related homeobox 2“
- TTF1:
-
„Thyroid transcription factor 1“
- PSA:
-
„Prostate specific antigen“
- PSAP:
-
„Prostate specific acid phosphatase“
- MIB1:
-
„Molecular immunology Borstel number 1“
- WT:
-
Warthin-Tumor
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Baumhoer, D., Pfaltz, M., Seydoux, J. et al. Warthin-Tumor mit Karzinom. Pathologe 30, 457–460 (2009). https://doi.org/10.1007/s00292-009-1208-2
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DOI: https://doi.org/10.1007/s00292-009-1208-2