Zusammenfassung
Der vorliegende Fallbericht beschreibt als Beispiel für Tumormultifokalität ein urotheliales Carcinoma in situ mit beginnender Stromainvasion im linken Ureter sowie begleitenden In-situ-Läsionen in Harnblase, Prostata und Samenblase. Die ungewöhnliche Manifestation eines urothelialen Carcinoma in situ in der Samenblase stellte sich nach Komplettaufarbeitung des Operationspräparates als flächige, intraepitheliale Tumorausbreitung über den Ductus ejaculatorius in die Samenblase dar. Vergleichende Sequenzierungen des Tumorsuppressorgens TP53 aus unterschiedlichen Lokalisationen zeigten durchweg Wildtypsequenzen.
Abstract
We report a case of multifocal urothelial carcinoma in situ of the left ureter with early stromal invasion and concomitant in situ lesions in bladder, prostate and seminal vesicle. After complete topographical mapping of the cystoprostatovesiculectomy specimen the unusual manifestation of urothelial carcinoma in situ in a seminal vesicle turned out to be a tumour spread via the ductus ejaculatorius into the seminal vesicle. DNA sequencing of the tumour suppressor gene TP53 of different tumour lesions revealed identical wild-type sequences.
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Gaisa, N., Donner, A., v. Serenyi, S. et al. Urotheliales Carcinoma in situ der Samenblasen – Ausdruck von Tumormultifokalität. Pathologe 29, 371–374 (2008). https://doi.org/10.1007/s00292-008-1010-6
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DOI: https://doi.org/10.1007/s00292-008-1010-6