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Expression des Angiotensin converting enzyme (ACE) bei pulmonaler Hypertonie

Expression of angiotensin I converting enzyme in pulmonary hypertension

  • Schwerpunkt: Lungen- und Pleurapathologie — Originalie
  • Published:
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Zusammenfasssung

In der vorliegenden Arbeit wurde überprüft, ob bei pulmonaler Hypertonie (PH) eine im Vergleich zu regelrechtem Lungengewebe vermehrte ACE-Expression vorliegt und diese mit bestimmten Hypertonieformen korreliert.

Die ACE-Antigenexpression wurde immunhistochemisch an 33 morphologisch regelrechten Lungengewebeproben (19 Männer, 32–77 J.; 14 Frauen, 34–93 J.) sowie Lungengewebeproben von 94 Patienten (67 Männer, 30–97 J.; 27 Frauen: 27–90 J.) mit klinisch gesicherter PH unterschiedlicher Genese (gemäß Venedig-Klassifikation) untersucht.

Es fand sich — unter Beibehaltung des in regelrechtem Lungengewebe nachweisbaren gefäßtypspezifischen Expressionsmusters — eine vermehrte ACE-Expression in Arterien sowie Arteriolen und Kapillaren bei den Proben mit pulmonal arterieller PH und PH infolge (chronischer) Thrombembolie bzw. Kollagenose. Hingegen war die ACE-Expression bei PH infolge Lungenerkrankung mit/ohne Hypoxie (COPD) bzw. Linksherzerkrankung nicht oder nur minimal vermehrt.

Die Untersuchungen bestätigen die bisher im Tierversuch nachgewiesene vermehrte ACE-Expression im arteriellen Gefäßschenkel in signifikantem Ausmaß nur für bestimmte PH-Formen. Diese Variation der ACE-Antigenexpression zwischen verschiedenen PH-Formen könnte für differenzierte therapeutische Ansätze (z. B. Wirksamkeit von ACE-Hemmern) bedeutsam sein.

Abstract

We studied angiotensin I converting enzyme (ACE) expression in lung tissue from patients with different forms of pulmonary hypertension (PH) in comparison with that from morphologically normal lung specimens.

ACE antigen expression was analysed by immunohistochemistry in morphologically normal lung tissue from 33 patients (19 males, 32–77 years; 14 females, 34–93 years) and compared to that in specimens from 94 patients (67 males, 30–97 years; 27 females: 27–90 years) with different clinically proven forms of PH (accordong to Venedig classification).

Type specific vessel expression pattern as described for normal lung tissue was generally intensified in arteries, arterioles and capillaries of the lung specimens with PH. Specimens with PH due to left heart disease and chronic obstructive pulmonary disease (COPD) showed only very weak or no augmented arterial ACE expression, while PH due to collagenoses or interstitial lung disease showed significantly higher ACE expression.

In human PH there is — comparable to animal models — a raised ACE expression in pulmonary lung vessels, with differences between the various forms of PH. These differences in ACE expression may be relevant for subtly differentiated therapeutic anti-ACE therapy regimes.

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Authors and Affiliations

  1. Institut für Pathologie der Ruhr-Universität Bochum, Berufsgenossenschaftliche Kliniken Bergmannsheil, Bochum

    A. M. Müller, M. Maas & U. Kozianka

  2. Institut für Pathologie, Justus-Liebig-Universität Gießen

    F. E. Franke

  3. Abt. für Kinderpathologie, Johannes Gutenberg-Universität, Langenbeckstraße 1, 55101, Mainz

    A. M. Müller

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  1. A. M. Müller
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Correspondence to A. M. Müller.

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Müller, A.M., Maas, M., Kozianka, U. et al. Expression des Angiotensin converting enzyme (ACE) bei pulmonaler Hypertonie. Pathologe 27, 133–139 (2006). https://doi.org/10.1007/s00292-006-0820-7

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  • DOI: https://doi.org/10.1007/s00292-006-0820-7

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