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Indikationen zur Pankreasbiopsie

Selten, aber zunehmend bedeutsamer

Indications for pancreatic biopsy

Uncommon, but increasingly more important

  • Schwerpunkt: Pankreaspathologie
  • Published:
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Zusammenfassung

Die Pankreasbiopsie steht als invasive und technisch schwierige Methode am Ende des diagnostischen Weges zur Abklärung einer tumorösen Pankreasläsion. Die unter ultrasonographischer, computertomographischer oder endosonographischer Kontrolle gezielt durchgeführte Feinnadelbiopsie ist eine treffsichere Methode geworden, die mit hoher Sensitivität und Spezifität die Diagnose eines duktalen Adenokarzinoms oder eines der seltenen Pankreastumoren sichert. Die wenigsten Komplikationen werden bei der Biopsie unter endosonographischer Kontrolle beobachtet. Die Gewebsentnahme aus einem nichtresektablen Pankreaskarzinom zum Nachweis von speziellen Markern oder Genmutationen, welche über den Einsatz besonderer Therapeutika entscheiden (z. B. EGF-R—Cetuximab), stellt eine neue Biopsieindikation dar.

Abstract

Pancreatic biopsy is an invasive diagnostic method that is only performed when all other diagnostic measures for establishing the diagnosis of a tumorous lesion of the pancreas have failed. Because of the advances in modern imaging techniques, fine needle biopsy of the pancreas guided by ultrasonography, computer tomography or endosonography has become a reliable method that allows the diagnosis of ductal adenocarcinoma or any of the other, rarer pancreatic tumors with high sensitivity and specificity. Complications are rare, particularly with the endosonographically guided biopsy. A new biopsy indication is the demonstration of certain markers or gene mutations that are needed for the initiation of special treatments, e.g. EGFR—Cetuximab.

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Authors and Affiliations

  1. II. Medizinische Universitätsklinik Mannheim

    J.-M. Löhr

  2. Institut für Allgemeine Pathologie, Universität Kiel

    G. Klöppel

  3. II. Medizinische Klinik, Fakultät für Klinische Medizin Mannheim der Universität Heidelberg, Theodor-Kutzer-Ufer 1–3, 68167, Mannheim

    J.-M. Löhr

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  2. G. Klöppel
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Correspondence to J.-M. Löhr.

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Löhr, JM., Klöppel, G. Indikationen zur Pankreasbiopsie. Pathologe 26, 67–72 (2005). https://doi.org/10.1007/s00292-004-0736-z

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