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Das Spektrum der chronischen Pankreatitis

Auf dem Weg zur ätiologischen Klassifikation

Spectrum of chronic pancreatitis

On the way to etiological classification


Die chronische Pankreatitis ist eine Erkrankung mit entzündlich-fibrosierender Genese, die durch Schädigungen der interstitiellen, duktalen und/oder azinären Zellen ausgelöst wird. Die wichtigsten Ursachen hierfür sind Alkoholabusus, Genmutationen, autoimmune Reaktionslage, anatomische Besonderheiten und Gangobstruktionen. Das morphologische Spektrum der chronischen Pankreatitisformen, welche sich mit den genannten Ätiologien verbinden, zeigt Unterschiede, die in zunehmendem Maße eine ursächliche Zuordnung gestatten. Für die Abgrenzung der chronischen Pankreatitis vom duktalen Adenokarzinom des Pankreas wird ein Katalog, der fünf Kriterien umfasst, vorgestellt.


Chronic pancreatitis is a fibroinflammatory disease that is induced by injuries to the interstitial, ductal, and/or acinar cells. The most important causes are alcohol abuse, gene mutations, autoimmune processes, special anatomic changes, and obstructive duct lesions. The morphologic spectrum of the various types of chronic pancreatitis related to the above causes shows features that increasingly allow an etiological distinction and categorization to be made. A catalog of five criteria is presented for distinguishing chronic pancreatitis from ductal adenocarcinoma of the pancreas.

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Klöppel, G., Sipos, B. & Lüttges, J. Das Spektrum der chronischen Pankreatitis. Pathologe 26, 59–66 (2005).

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