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Azinuszellkarzinome und Pankreatoblastome

Verwandt und doch unterschiedlich

Acinar cell carcinomas and pancreatoblastomas: related but not the same

Zusammenfassung

Azinuszellkarzinome und Pankreatoblastome sind maligne Pankreastumoren mit vornehmlich azinärer Differenzierung und der damit verbundenen immunhistochemischen Expression von Pankreasenzymen. Histologisch zeigen die Zellen azinusartige und/oder solide Strukturen, sie können aber gelegentlich auch zystisch aufgebaut sein. Ein Spezifikum der Pankreatoblastome ist das Auftreten von squamoiden Nestern. Azinuszellkarzinome kommen bevorzugt bei Erwachsenen, Pankreatoblastome bei Kindern vor. Bei beiden Tumortypen finden sich ein Allelverlust in der Chromosomregion 11p und Mutationen in dem APC/β-Catenin-Signalweg. Pankreatoblastome sind im Gegensatz zu den Azinuszellkarzinomen potenziell heilbar.

Abstract

Acinar cell carcinomas and pancreatoblastomas are malignant tumors of the pancreas, showing predominantly acinar differentiation characterized by the immunohistochemical expression of pancreatic enzymes. Histologically, they usually display acinar and/or solid patterns, but may occasionally also exhibit cystic structures. The key feature of pancreatoblastomas is the presence of squamoid corpuscles. Acinar cell carcinomas predominantly occur in adults, pancreatoblastomas in children. Both tumor types commonly show allelic losses on chromosome 11p and mutations in the APC/ß-catenin signaling pathway. Pancreatoblastomas, in contrast to acinar cell carcinomas, are potentially curable.

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Sipos, B., Klöppel, G. Azinuszellkarzinome und Pankreatoblastome. Pathologe 26, 37–40 (2005). https://doi.org/10.1007/s00292-004-0732-3

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Schlüsselwörter

  • Azinuszellkarzinom
  • Pankreatoblastom
  • Pathologie
  • Diffferenzialdiagnose
  • Genetische Aberrationen

Keywords

  • Acinar cell carcinoma
  • Pancreatoblastoma
  • Pathology
  • Differential diagnosis
  • Genetic aberrations